Laughton CA - Search Results

1

GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors.

Emtage AL, Mistry SN, Fischer PM, Kellam B, Laughton CA. Emtage AL, et al. Among authors: laughton ca. J Biomol Struct Dyn. 2017 Sep;35(12):2604-2619. doi: 10.1080/07391102.2016.1226197. Epub 2016 Sep 1. J Biomol Struct Dyn. 2017. PMID: 27532213

2

Exploiting glycogen synthase kinase 3beta flexibility in molecular recognition.

Mazanetz MP, Withers IM, Laughton CA, Fischer PM. Mazanetz MP, et al. Among authors: laughton ca. Biochem Soc Trans. 2008 Feb;36(Pt 1):55-8. doi: 10.1042/BST0360055. Biochem Soc Trans. 2008. PMID: 18208385

3

Active site pressurization: a new tool for structure-guided drug design and other studies of protein flexibility.

Withers IM, Mazanetz MP, Wang H, Fischer PM, Laughton CA. Withers IM, et al. Among authors: laughton ca. J Chem Inf Model. 2008 Jul;48(7):1448-54. doi: 10.1021/ci7004725. Epub 2008 Jun 14. J Chem Inf Model. 2008. PMID: 18553961

4

Long-timescale molecular-dynamics simulations of the major urinary protein provide atomistic interpretations of the unusual thermodynamics of ligand binding.

Roy J, Laughton CA. Roy J, et al. Among authors: laughton ca. Biophys J. 2010 Jul 7;99(1):218-26. doi: 10.1016/j.bpj.2010.03.055. Biophys J. 2010. PMID: 20655850 Free PMC article.

5

Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines.

Mohammed MZ, Vyjayanti VN, Laughton CA, Dekker LV, Fischer PM, Wilson DM 3rd, Abbotts R, Shah S, Patel PM, Hickson ID, Madhusudan S. Mohammed MZ, et al. Among authors: laughton ca. Br J Cancer. 2011 Feb 15;104(4):653-63. doi: 10.1038/sj.bjc.6606058. Epub 2011 Jan 25. Br J Cancer. 2011. PMID: 21266972 Free PMC article.

6

Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.

Sultana R, McNeill DR, Abbotts R, Mohammed MZ, Zdzienicka MZ, Qutob H, Seedhouse C, Laughton CA, Fischer PM, Patel PM, Wilson DM 3rd, Madhusudan S. Sultana R, et al. Among authors: laughton ca. Int J Cancer. 2012 Nov 15;131(10):2433-44. doi: 10.1002/ijc.27512. Epub 2012 Mar 28. Int J Cancer. 2012. PMID: 22377908 Free PMC article.

7

Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers.

Vernall AJ, Stoddart LA, Briddon SJ, Ng HW, Laughton CA, Doughty SW, Hill SJ, Kellam B. Vernall AJ, et al. Among authors: laughton ca. Org Biomol Chem. 2013 Sep 14;11(34):5673-82. doi: 10.1039/c3ob41221k. Org Biomol Chem. 2013. PMID: 23881285

8

Investigating the binding preferences of small molecule inhibitors of human protein arginine methyltransferase 1 using molecular modelling.

Hong W, Li J, Laughton CA, Yap LF, Paterson IC, Wang H. Hong W, et al. Among authors: laughton ca. J Mol Graph Model. 2014 Jun;51:193-202. doi: 10.1016/j.jmgm.2014.05.010. Epub 2014 Jun 4. J Mol Graph Model. 2014. PMID: 24937176

9

Investigation of the flexibility of protein kinases implicated in the pathology of Alzheimer's disease.

Mazanetz MP, Laughton CA, Fischer PM. Mazanetz MP, et al. Among authors: laughton ca. Molecules. 2014 Jun 30;19(7):9134-59. doi: 10.3390/molecules19079134. Molecules. 2014. PMID: 24983862 Free PMC article.

10

The fitness burden imposed by synthesising quorum sensing signals.

Ruparell A, Dubern JF, Ortori CA, Harrison F, Halliday NM, Emtage A, Ashawesh MM, Laughton CA, Diggle SP, Williams P, Barrett DA, Hardie KR. Ruparell A, et al. Among authors: laughton ca. Sci Rep. 2016 Sep 12;6:33101. doi: 10.1038/srep33101. Sci Rep. 2016. PMID: 27616328 Free PMC article.

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