Laudon H - Search Results

1

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease.

Gustavsson T, Metzendorf NG, Wik E, Roshanbin S, Julku U, Chourlia A, Nilsson P, Andersson KG, Laudon H, Hultqvist G, Syvänen S, Sehlin D. Gustavsson T, et al. Among authors: laudon h. Alzheimers Res Ther. 2023 May 2;15(1):90. doi: 10.1186/s13195-023-01236-3. Alzheimers Res Ther. 2023. PMID: 37131196 Free PMC article.

2

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody.

Syvänen S, Hultqvist G, Gustavsson T, Gumucio A, Laudon H, Söderberg L, Ingelsson M, Lannfelt L, Sehlin D. Syvänen S, et al. Among authors: laudon h. Alzheimers Res Ther. 2018 May 24;10(1):49. doi: 10.1186/s13195-018-0377-8. Alzheimers Res Ther. 2018. PMID: 29793530 Free PMC article.

3

The murine version of BAN2401 (mAb158) selectively reduces amyloid-β protofibrils in brain and cerebrospinal fluid of tg-ArcSwe mice.

Tucker S, Möller C, Tegerstedt K, Lord A, Laudon H, Sjödahl J, Söderberg L, Spens E, Sahlin C, Waara ER, Satlin A, Gellerfors P, Osswald G, Lannfelt L. Tucker S, et al. Among authors: laudon h. J Alzheimers Dis. 2015;43(2):575-88. doi: 10.3233/JAD-140741. J Alzheimers Dis. 2015. PMID: 25096615

4

Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease.

Söderberg L, Johannesson M, Nygren P, Laudon H, Eriksson F, Osswald G, Möller C, Lannfelt L. Söderberg L, et al. Among authors: laudon h. Neurotherapeutics. 2023 Jan;20(1):195-206. doi: 10.1007/s13311-022-01308-6. Epub 2022 Oct 17. Neurotherapeutics. 2023. PMID: 36253511 Free PMC article.

5

APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.

Bergman A, Religa D, Karlström H, Laudon H, Winblad B, Lannfelt L, Lundkvist J, Näslund J. Bergman A, et al. Among authors: laudon h. Exp Cell Res. 2003 Jul 1;287(1):1-9. doi: 10.1016/s0014-4827(03)00117-4. Exp Cell Res. 2003. PMID: 12799176

6

Amyloid beta pathology in Alzheimer's disease and schizophrenia.

Religa D, Laudon H, Styczynska M, Winblad B, Näslund J, Haroutunian V. Religa D, et al. Among authors: laudon h. Am J Psychiatry. 2003 May;160(5):867-72. doi: 10.1176/appi.ajp.160.5.867. Am J Psychiatry. 2003. PMID: 12727689

7

The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.

Laudon H, Winblad B, Näslund J. Laudon H, et al. Physiol Behav. 2007 Sep 10;92(1-2):115-20. doi: 10.1016/j.physbeh.2007.05.037. Epub 2007 May 21. Physiol Behav. 2007. PMID: 17588625 Review.

8

The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.

Wanngren J, Frånberg J, Svensson AI, Laudon H, Olsson F, Winblad B, Liu F, Näslund J, Lundkvist J, Karlström H. Wanngren J, et al. Among authors: laudon h. J Biol Chem. 2010 Mar 19;285(12):8527-36. doi: 10.1074/jbc.M109.055590. Epub 2010 Jan 27. J Biol Chem. 2010. PMID: 20106965 Free PMC article.

9

Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.

Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J. Laudon H, et al. J Neurochem. 2004 Apr;89(1):44-53. doi: 10.1046/j.1471-4159.2003.02298.x. J Neurochem. 2004. PMID: 15030388 Free article.

10

Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.

Hansson CA, Popescu BO, Laudon H, Cedazo-Minguez A, Popescu LM, Winblad B, Ankarcrona M. Hansson CA, et al. Among authors: laudon h. J Neurochem. 2006 Apr;97(2):356-64. doi: 10.1111/j.1471-4159.2006.03735.x. Epub 2006 Mar 15. J Neurochem. 2006. PMID: 16539675 Free article.

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