Lau ST - Search Results

1

Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses.

Lau ST, Li Z, Pui-Ling Lai F, Nga-Chu Lui K, Li P, Munera JO, Pan G, Mahe MM, Hui CC, Wells JM, Ngan ES. Lau ST, et al. Gastroenterology. 2019 Dec;157(6):1556-1571.e5. doi: 10.1053/j.gastro.2019.08.019. Epub 2019 Aug 20. Gastroenterology. 2019. PMID: 31442438

2

Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans.

Ngan ES, Garcia-Barceló MM, Yip BH, Poon HC, Lau ST, Kwok CK, Sat E, Sham MH, Wong KK, Wainwright BJ, Cherny SS, Hui CC, Sham PC, Lui VC, Tam PK. Ngan ES, et al. Among authors: lau st. J Clin Invest. 2011 Sep;121(9):3467-78. doi: 10.1172/JCI43737. Epub 2011 Aug 15. J Clin Invest. 2011. PMID: 21841314 Free PMC article.

3

Dysregulation of clathrin promotes thyroid cell growth and contributes to multinodular goiter pathogenesis.

Lau ST, Zhou T, Liu JA, Fung EY, Che CM, Lang BH, Ngan ES. Lau ST, et al. Biochim Biophys Acta. 2015 Aug;1852(8):1676-86. doi: 10.1016/j.bbadis.2015.05.005. Epub 2015 May 13. Biochim Biophys Acta. 2015. PMID: 25981745 Free article.

4

Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function.

Lai FP, Lau ST, Wong JK, Gui H, Wang RX, Zhou T, Lai WH, Tse HF, Tam PK, Garcia-Barcelo MM, Ngan ES. Lai FP, et al. Among authors: lau st. Gastroenterology. 2017 Jul;153(1):139-153.e8. doi: 10.1053/j.gastro.2017.03.014. Epub 2017 Mar 23. Gastroenterology. 2017. PMID: 28342760 Free article.

5

Identification of Genes Associated With Hirschsprung Disease, Based on Whole-Genome Sequence Analysis, and Potential Effects on Enteric Nervous System Development.

Tang CS, Li P, Lai FP, Fu AX, Lau ST, So MT, Lui KN, Li Z, Zhuang X, Yu M, Liu X, Ngo ND, Miao X, Zhang X, Yi B, Tang S, Sun X, Zhang F, Liu H, Liu Q, Zhang R, Wang H, Huang L, Dong X, Tou J, Cheah KS, Yang W, Yuan Z, Yip KY, Sham PC, Tam PK, Garcia-Barcelo MM, Ngan ES. Tang CS, et al. Among authors: lau st. Gastroenterology. 2018 Dec;155(6):1908-1922.e5. doi: 10.1053/j.gastro.2018.09.012. Epub 2018 Sep 12. Gastroenterology. 2018. PMID: 30217742

6

Whole-genome analysis of noncoding genetic variations identifies multiscale regulatory element perturbations associated with Hirschsprung disease.

Fu AX, Lui KN, Tang CS, Ng RK, Lai FP, Lau ST, Li Z, Garcia-Barcelo MM, Sham PC, Tam PK, Ngan ES, Yip KY. Fu AX, et al. Among authors: lau st. Genome Res. 2020 Nov;30(11):1618-1632. doi: 10.1101/gr.264473.120. Epub 2020 Sep 18. Genome Res. 2020. PMID: 32948616 Free PMC article.

7

Ciliary protein Kif7 regulates Gli and Ezh2 for initiating the neuronal differentiation of enteric neural crest cells during development.

Lai FP, Li Z, Zhou T, Leung AOW, Lau ST, Lui KN, Wong WY, Sham PC, Hui CC, Ngan ES. Lai FP, et al. Among authors: lau st. Sci Adv. 2021 Oct 15;7(42):eabf7472. doi: 10.1126/sciadv.abf7472. Epub 2021 Oct 13. Sci Adv. 2021. PMID: 34644112 Free PMC article.

8

Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation.

Li Z, Lui KN, Lau ST, Lai FP, Li P, Chung PH, Wong KK, Tam PK, Garica-Barcelo MM, Hui CC, Sham PC, Ngan ES. Li Z, et al. Among authors: lau st. Nat Commun. 2023 Apr 15;14(1):2157. doi: 10.1038/s41467-023-37928-5. Nat Commun. 2023. PMID: 37061531 Free PMC article.

9

Organoid models of breathing disorders reveal patterning defect of hindbrain neurons caused by PHOX2B-PARMs.

Lui KN, Li Z, Lai FP, Lau ST, Ngan ES. Lui KN, et al. Among authors: lau st. Stem Cell Reports. 2023 Jul 11;18(7):1500-1515. doi: 10.1016/j.stemcr.2023.05.020. Epub 2023 Jun 22. Stem Cell Reports. 2023. PMID: 37352849 Free PMC article.

10

Coexisting ductal carcinoma in situ independently predicts lower tumor aggressiveness in node-positive luminal breast cancer.

Wong H, Lau S, Leung R, Chiu J, Cheung P, Wong TT, Liang R, Epstein RJ, Yau T. Wong H, et al. Med Oncol. 2012 Sep;29(3):1536-42. doi: 10.1007/s12032-011-0082-y. Epub 2011 Oct 8. Med Oncol. 2012. PMID: 21983862

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