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Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.
Krishnan SM, Ling YH, Huuskes BM, Ferens DM, Saini N, Chan CT, Diep H, Kett MM, Samuel CS, Kemp-Harper BK, Robertson AAB, Cooper MA, Peter K, Latz E, Mansell AS, Sobey CG, Drummond GR, Vinh A. Krishnan SM, et al. Among authors: latz e. Cardiovasc Res. 2019 Mar 15;115(4):776-787. doi: 10.1093/cvr/cvy252. Cardiovasc Res. 2019. PMID: 30357309 Free PMC article.
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E. Bauernfeind FG, et al. Among authors: latz e. J Immunol. 2009 Jul 15;183(2):787-91. doi: 10.4049/jimmunol.0901363. Epub 2009 Jul 1. J Immunol. 2009. PMID: 19570822 Free PMC article.
Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
Kim S, Bauernfeind F, Ablasser A, Hartmann G, Fitzgerald KA, Latz E, Hornung V. Kim S, et al. Among authors: latz e. Eur J Immunol. 2010 Jun;40(6):1545-51. doi: 10.1002/eji.201040425. Eur J Immunol. 2010. PMID: 20333626 Free PMC article.
NLRP3 inflammasomes link inflammation and metabolic disease.
De Nardo D, Latz E. De Nardo D, et al. Among authors: latz e. Trends Immunol. 2011 Aug;32(8):373-9. doi: 10.1016/j.it.2011.05.004. Epub 2011 Jul 4. Trends Immunol. 2011. PMID: 21733753 Free PMC article. Review.
PKR stirs up inflammasomes.
Stunden HJ, Latz E. Stunden HJ, et al. Among authors: latz e. Cell Res. 2013 Feb;23(2):168-70. doi: 10.1038/cr.2012.125. Epub 2012 Sep 4. Cell Res. 2013. PMID: 22945351 Free PMC article.
328 results