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Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease.
Zaręba P, Łątka K, Mazur G, Gryzło B, Pasieka A, Godyń J, Panek D, Skrzypczak-Wiercioch A, Höfner GC, Latacz G, Maj M, Espargaró A, Sabaté R, Jóźwiak K, Wanner KT, Sałat K, Malawska B, Kulig K, Bajda M. Zaręba P, et al. Among authors: latacz g. Eur J Med Chem. 2023 Dec 5;261:115832. doi: 10.1016/j.ejmech.2023.115832. Epub 2023 Oct 7. Eur J Med Chem. 2023. PMID: 37837674 Free article.
Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands.
Łażewska D, Więcek M, Ner J, Kamińska K, Kottke T, Schwed JS, Zygmunt M, Karcz T, Olejarz A, Kuder K, Latacz G, Grosicki M, Sapa J, Karolak-Wojciechowska J, Stark H, Kieć-Kononowicz K. Łażewska D, et al. Among authors: latacz g. Eur J Med Chem. 2014 Aug 18;83:534-46. doi: 10.1016/j.ejmech.2014.06.032. Epub 2014 Jun 17. Eur J Med Chem. 2014. PMID: 24996140
(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands.
Kamińska K, Ziemba J, Ner J, Schwed JS, Łażewska D, Więcek M, Karcz T, Olejarz A, Latacz G, Kuder K, Kottke T, Zygmunt M, Sapa J, Karolak-Wojciechowska J, Stark H, Kieć-Kononowicz K. Kamińska K, et al. Among authors: latacz g. Eur J Med Chem. 2015 Oct 20;103:238-51. doi: 10.1016/j.ejmech.2015.08.014. Epub 2015 Aug 10. Eur J Med Chem. 2015. PMID: 26360048
Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation.
Kucwaj-Brysz K, Warszycki D, Podlewska S, Witek J, Witek K, González Izquierdo A, Satała G, Loza MI, Lubelska A, Latacz G, Bojarski AJ, Castro M, Kieć-Kononowicz K, Handzlik J. Kucwaj-Brysz K, et al. Among authors: latacz g. Eur J Med Chem. 2016 Apr 13;112:258-269. doi: 10.1016/j.ejmech.2016.02.024. Epub 2016 Feb 9. Eur J Med Chem. 2016. PMID: 26900658
Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease.
Więckowska A, Wichur T, Godyń J, Bucki A, Marcinkowska M, Siwek A, Więckowski K, Zaręba P, Knez D, Głuch-Lutwin M, Kazek G, Latacz G, Mika K, Kołaczkowski M, Korabecny J, Soukup O, Benkova M, Kieć-Kononowicz K, Gobec S, Malawska B. Więckowska A, et al. Among authors: latacz g. ACS Chem Neurosci. 2018 May 16;9(5):1195-1214. doi: 10.1021/acschemneuro.8b00024. Epub 2018 Feb 13. ACS Chem Neurosci. 2018. PMID: 29384656
Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands.
Szczepańska K, Karcz T, Mogilski S, Siwek A, Kuder KJ, Latacz G, Kubacka M, Hagenow S, Lubelska A, Olejarz A, Kotańska M, Sadek B, Stark H, Kieć-Kononowicz K. Szczepańska K, et al. Among authors: latacz g. Eur J Med Chem. 2018 May 25;152:223-234. doi: 10.1016/j.ejmech.2018.04.043. Epub 2018 Apr 25. Eur J Med Chem. 2018. PMID: 29723785
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.
Załuski M, Schabikowski J, Schlenk M, Olejarz-Maciej A, Kubas B, Karcz T, Kuder K, Latacz G, Zygmunt M, Synak D, Hinz S, Müller CE, Kieć-Kononowicz K. Załuski M, et al. Among authors: latacz g. Bioorg Med Chem. 2019 Apr 1;27(7):1195-1210. doi: 10.1016/j.bmc.2019.02.004. Epub 2019 Feb 2. Bioorg Med Chem. 2019. PMID: 30808606
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6.
Ali W, Więcek M, Łażewska D, Kurczab R, Jastrzębska-Więsek M, Satała G, Kucwaj-Brysz K, Lubelska A, Głuch-Lutwin M, Mordyl B, Siwek A, Nasim MJ, Partyka A, Sudoł S, Latacz G, Wesołowska A, Kieć-Kononowicz K, Handzlik J. Ali W, et al. Among authors: latacz g. Eur J Med Chem. 2019 Sep 15;178:740-751. doi: 10.1016/j.ejmech.2019.06.022. Epub 2019 Jun 10. Eur J Med Chem. 2019. PMID: 31229876
Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma.
Ali W, Spengler G, Kincses A, Nové M, Battistelli C, Latacz G, Starek M, Dąbrowska M, Honkisz-Orzechowska E, Romanelli A, Rasile MM, Szymańska E, Jacob C, Zwergel C, Handzlik J. Ali W, et al. Among authors: latacz g. Eur J Med Chem. 2020 Aug 15;200:112435. doi: 10.1016/j.ejmech.2020.112435. Epub 2020 May 15. Eur J Med Chem. 2020. PMID: 32505850
120 results