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Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one.
Bouley R, Kumarasiri M, Peng Z, Otero LH, Song W, Suckow MA, Schroeder VA, Wolter WR, Lastochkin E, Antunes NT, Pi H, Vakulenko S, Hermoso JA, Chang M, Mobashery S. Bouley R, et al. Among authors: lastochkin e. J Am Chem Soc. 2015 Feb 11;137(5):1738-41. doi: 10.1021/jacs.5b00056. Epub 2015 Feb 2. J Am Chem Soc. 2015. PMID: 25629446 Free PMC article.
Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity.
O'Daniel PI, Peng Z, Pi H, Testero SA, Ding D, Spink E, Leemans E, Boudreau MA, Yamaguchi T, Schroeder VA, Wolter WR, Llarrull LI, Song W, Lastochkin E, Kumarasiri M, Antunes NT, Espahbodi M, Lichtenwalter K, Suckow MA, Vakulenko S, Mobashery S, Chang M. O'Daniel PI, et al. Among authors: lastochkin e. J Am Chem Soc. 2014 Mar 5;136(9):3664-72. doi: 10.1021/ja500053x. Epub 2014 Feb 21. J Am Chem Soc. 2014. PMID: 24517363 Free PMC article.
Structure-activity relationship for the oxadiazole class of antibiotics.
Spink E, Ding D, Peng Z, Boudreau MA, Leemans E, Lastochkin E, Song W, Lichtenwalter K, O'Daniel PI, Testero SA, Pi H, Schroeder VA, Wolter WR, Antunes NT, Suckow MA, Vakulenko S, Chang M, Mobashery S. Spink E, et al. Among authors: lastochkin e. J Med Chem. 2015 Feb 12;58(3):1380-9. doi: 10.1021/jm501661f. Epub 2015 Jan 30. J Med Chem. 2015. PMID: 25590813 Free PMC article.
Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials.
Bouley R, Ding D, Peng Z, Bastian M, Lastochkin E, Song W, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M. Bouley R, et al. Among authors: lastochkin e. J Med Chem. 2016 May 26;59(10):5011-21. doi: 10.1021/acs.jmedchem.6b00372. Epub 2016 May 5. J Med Chem. 2016. PMID: 27088777 Free PMC article.
Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials.
Qian Y, Allegretta G, Janardhanan J, Peng Z, Mahasenan KV, Lastochkin E, Gozun MMN, Tejera S, Schroeder VA, Wolter WR, Feltzer R, Mobashery S, Chang M. Qian Y, et al. Among authors: lastochkin e. J Med Chem. 2020 May 28;63(10):5287-5296. doi: 10.1021/acs.jmedchem.0c00153. Epub 2020 May 8. J Med Chem. 2020. PMID: 32343145 Free PMC article.
Reactions of the three AmpD enzymes of Pseudomonas aeruginosa.
Zhang W, Lee M, Hesek D, Lastochkin E, Boggess B, Mobashery S. Zhang W, et al. Among authors: lastochkin e. J Am Chem Soc. 2013 Apr 3;135(13):4950-3. doi: 10.1021/ja400970n. Epub 2013 Mar 21. J Am Chem Soc. 2013. PMID: 23510438 Free PMC article.
39 results