Last K - Search Results

1

Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.

Struglics A, Lohmander LS, Last K, Akikusa J, Allen R, Fosang AJ. Struglics A, et al. Among authors: last k. Arthritis Rheum. 2012 Dec;64(12):4151-61; author reply 4162-3. doi: 10.1002/art.34665. Arthritis Rheum. 2012. PMID: 22886575 Free article.

2

Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan.

Fosang AJ, Last K, Stanton H, Golub SB, Little CB, Brown L, Jackson DC. Fosang AJ, et al. Among authors: last k. Methods Mol Biol. 2010;622:312-47. doi: 10.1007/978-1-60327-299-5_19. Methods Mol Biol. 2010. PMID: 20135291

3

Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice.

Rogerson FM, Chung YM, Deutscher ME, Last K, Fosang AJ. Rogerson FM, et al. Among authors: last k. Arthritis Rheum. 2010 Nov;62(11):3365-73. doi: 10.1002/art.27661. Arthritis Rheum. 2010. PMID: 20662062 Free article.

4

Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.

Fosang AJ, Last K, Maciewicz RA. Fosang AJ, et al. Among authors: last k. J Clin Invest. 1996 Nov 15;98(10):2292-9. doi: 10.1172/JCI119040. J Clin Invest. 1996. PMID: 8941646 Free PMC article.

Based on their size relative to characterized products of an MMP-8 digest (Fosang, A.J., K. Last, P. Gardiner, D.C. Jackson, and L. Brown. 1995, Biochem. ...

Based on their size relative to characterized products of an MMP-8 digest (Fosang, A.J., K. Last, P. Gardiner, D.C. Jackson, a …

5

Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan.

Fosang AJ, Last K, Poon CJ, Plaas AH. Fosang AJ, et al. Among authors: last k. Matrix Biol. 2009 Jan;28(1):53-61. doi: 10.1016/j.matbio.2008.11.001. Epub 2008 Nov 12. Matrix Biol. 2009. PMID: 19041721

6

N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity.

Poon CJ, Plaas AH, Keene DR, McQuillan DJ, Last K, Fosang AJ. Poon CJ, et al. Among authors: last k. J Biol Chem. 2005 Jun 24;280(25):23615-21. doi: 10.1074/jbc.M412145200. Epub 2005 Apr 22. J Biol Chem. 2005. PMID: 15849197 Free article.

7

Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2.

Lees S, Golub SB, Last K, Zeng W, Jackson DC, Sutton P, Fosang AJ. Lees S, et al. Among authors: last k. Arthritis Rheumatol. 2015 May;67(5):1240-9. doi: 10.1002/art.39063. Arthritis Rheumatol. 2015. PMID: 25707860

8

Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain.

Fosang AJ, Last K, Fujii Y, Seiki M, Okada Y. Fosang AJ, et al. Among authors: last k. FEBS Lett. 1998 Jul 3;430(3):186-90. doi: 10.1016/s0014-5793(98)00667-x. FEBS Lett. 1998. PMID: 9688535 Free article.

9

ADAMTS-9 in Mouse Cartilage Has Aggrecanase Activity That Is Distinct from ADAMTS-4 and ADAMTS-5.

Rogerson FM, Last K, Golub SB, Gauci SJ, Stanton H, Bell KM, Fosang AJ. Rogerson FM, et al. Among authors: last k. Int J Mol Sci. 2019 Jan 29;20(3):573. doi: 10.3390/ijms20030573. Int J Mol Sci. 2019. PMID: 30699963 Free PMC article.

10

Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids.

Fosang AJ, Last K, Gardiner P, Jackson DC, Brown L. Fosang AJ, et al. Among authors: last k. Biochem J. 1995 Aug 15;310 ( Pt 1)(Pt 1):337-43. doi: 10.1042/bj3100337. Biochem J. 1995. PMID: 7544117 Free PMC article.

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