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Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis.
Bettencourt C, Piras IS, Foti SC, Talboom J, Miki Y, Lashley T, Balazs R, Viré E, Warner TT, Huentelman MJ, Holton JL. Bettencourt C, et al. Among authors: lashley t. Acta Neuropathol Commun. 2020 May 14;8(1):71. doi: 10.1186/s40478-020-00946-1. Acta Neuropathol Commun. 2020. PMID: 32410669 Free PMC article. No abstract available.
Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations.
Houlden H, Baker M, McGowan E, Lewis P, Hutton M, Crook R, Wood NW, Kumar-Singh S, Geddes J, Swash M, Scaravilli F, Holton JL, Lashley T, Tomita T, Hashimoto T, Verkkoniemi A, Kalimo H, Somer M, Paetau A, Martin JJ, Van Broeckhoven C, Golde T, Hardy J, Haltia M, Revesz T. Houlden H, et al. Among authors: lashley t. Ann Neurol. 2000 Nov;48(5):806-8. Ann Neurol. 2000. PMID: 11079548
Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia.
Holton JL, Ghiso J, Lashley T, Rostagno A, Guerin CJ, Gibb G, Houlden H, Ayling H, Martinian L, Anderton BH, Wood NW, Vidal R, Plant G, Frangione B, Revesz T. Holton JL, et al. Among authors: lashley t. Am J Pathol. 2001 Feb;158(2):515-26. doi: 10.1016/S0002-9440(10)63993-4. Am J Pathol. 2001. PMID: 11159188 Free PMC article.
Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.
Holton JL, Lashley T, Ghiso J, Braendgaard H, Vidal R, Guerin CJ, Gibb G, Hanger DP, Rostagno A, Anderton BH, Strand C, Ayling H, Plant G, Frangione B, Bojsen-Møller M, Revesz T. Holton JL, et al. Among authors: lashley t. J Neuropathol Exp Neurol. 2002 Mar;61(3):254-67. doi: 10.1093/jnen/61.3.254. J Neuropathol Exp Neurol. 2002. PMID: 11895040
Sporadic and familial cerebral amyloid angiopathies.
Revesz T, Holton JL, Lashley T, Plant G, Rostagno A, Ghiso J, Frangione B. Revesz T, et al. Among authors: lashley t. Brain Pathol. 2002 Jul;12(3):343-57. doi: 10.1111/j.1750-3639.2002.tb00449.x. Brain Pathol. 2002. PMID: 12146803 Free PMC article. Review.
Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies.
de Silva R, Lashley T, Gibb G, Hanger D, Hope A, Reid A, Bandopadhyay R, Utton M, Strand C, Jowett T, Khan N, Anderton B, Wood N, Holton J, Revesz T, Lees A. de Silva R, et al. Among authors: lashley t. Neuropathol Appl Neurobiol. 2003 Jun;29(3):288-302. doi: 10.1046/j.1365-2990.2003.00463.x. Neuropathol Appl Neurobiol. 2003. PMID: 12787326
An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies.
de Silva R, Lashley T, Strand C, Shiarli AM, Shi J, Tian J, Bailey KL, Davies P, Bigio EH, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, Halliday G, MacKenzie J, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM, Holton J, Lees A, Revesz T, Mann DM. de Silva R, et al. Among authors: lashley t. Acta Neuropathol. 2006 Apr;111(4):329-40. doi: 10.1007/s00401-006-0048-x. Epub 2006 Mar 22. Acta Neuropathol. 2006. PMID: 16552612
192 results