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43 results

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Page 1
Therapeutic targeting of immunometabolism in Alzheimer's disease reveals a critical reliance on Hexokinase 2 dosage on microglial activation and disease progression.
Codocedo JF, Mera-Reina C, Lin PB, Puntambekar SS, Casali BT, Jury N, Martinez P, Lasagna-Reeves CA, Landreth GE. Codocedo JF, et al. Among authors: lasagna reeves ca. bioRxiv [Preprint]. 2023 Nov 15:2023.11.11.566270. doi: 10.1101/2023.11.11.566270. bioRxiv. 2023. PMID: 38014106 Free PMC article. Preprint.
Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation.
Ramirez E, Ganegamage SK, Min S, Patel H, Ogunware A, Plascencia-Villa G, Alnakhala H, Shimanaka K, Tripathi A, Wang KW, Zhu X, Rochet JC, Kuo MH, Counts SE, Perry G, Dettmer U, Lasagna-Reeves CA, Fortin JS. Ramirez E, et al. Among authors: lasagna reeves ca. ACS Chem Neurosci. 2023 Nov 1;14(21):3913-3927. doi: 10.1021/acschemneuro.3c00464. Epub 2023 Oct 11. ACS Chem Neurosci. 2023. PMID: 37818657 Free article.
Network analysis identifies strain-dependent response to tau and tau seeding-associated genes.
Acri DJ, You Y, Tate MD, Karahan H, Martinez P, McCord B, Sharify AD, John S, Kim B, Dabin LC, Philtjens S, Wijeratne HRS, McCray TJ, Smith DC, Bissel SJ, Lamb BT, Lasagna-Reeves CA, Kim J. Acri DJ, et al. Among authors: lasagna reeves ca. J Exp Med. 2023 Nov 6;220(11):e20230180. doi: 10.1084/jem.20230180. Epub 2023 Aug 22. J Exp Med. 2023. PMID: 37606887 Free PMC article.
Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer's disease.
Jury-Garfe N, You Y, Martínez P, Redding-Ochoa J, Karahan H, Johnson TS, Zhang J, Kim J, Troncoso JC, Lasagna-Reeves CA. Jury-Garfe N, et al. Among authors: lasagna reeves ca. bioRxiv [Preprint]. 2023 Jul 28:2023.07.27.550884. doi: 10.1101/2023.07.27.550884. bioRxiv. 2023. PMID: 37546928 Free PMC article. Preprint.
TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo.
Lee-Gosselin A, Jury-Garfe N, You Y, Dabin L, Soni D, Dutta S, Rochet JC, Kim J, Oblak AL, Lasagna-Reeves CA. Lee-Gosselin A, et al. Among authors: lasagna reeves ca. Cells. 2023 Jun 10;12(12):1597. doi: 10.3390/cells12121597. Cells. 2023. PMID: 37371067 Free PMC article.
TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation.
Moutinho M, Coronel I, Tsai AP, Di Prisco GV, Pennington T, Atwood BK, Puntambekar SS, Smith DC, Martinez P, Han S, Lee Y, Lasagna-Reeves CA, Lamb BT, Bissel SJ, Nho K, Landreth GE. Moutinho M, et al. Among authors: lasagna reeves ca. Genome Med. 2023 Feb 20;15(1):11. doi: 10.1186/s13073-023-01160-z. Genome Med. 2023. PMID: 36805764 Free PMC article.
Network analysis reveals strain-dependent response to misfolded tau aggregates.
Acri DJ, You Y, Tate MD, McCord B, Sharify AD, John S, Karahan H, Kim B, Dabin LC, Philtjens S, Wijeratne HRS, McCray TJ, Smith DC, Bissel SJ, Lamb BT, Lasagna-Reeves CA, Kim J. Acri DJ, et al. Among authors: lasagna reeves ca. bioRxiv [Preprint]. 2023 Jan 30:2023.01.28.526029. doi: 10.1101/2023.01.28.526029. bioRxiv. 2023. PMID: 36778440 Free PMC article. Preprint.
Bassoon contributes to tau-seed propagation and neurotoxicity.
Martinez P, Patel H, You Y, Jury N, Perkins A, Lee-Gosselin A, Taylor X, You Y, Viana Di Prisco G, Huang X, Dutta S, Wijeratne AB, Redding-Ochoa J, Shahid SS, Codocedo JF, Min S, Landreth GE, Mosley AL, Wu YC, McKinzie DL, Rochet JC, Zhang J, Atwood BK, Troncoso J, Lasagna-Reeves CA. Martinez P, et al. Among authors: lasagna reeves ca. Nat Neurosci. 2022 Dec;25(12):1597-1607. doi: 10.1038/s41593-022-01191-6. Epub 2022 Nov 7. Nat Neurosci. 2022. PMID: 36344699 Free PMC article.
The reduction of astrocytic tau prevents amyloid-β-induced synaptotoxicity.
Cisternas P, Taylor X, Martinez P, Maldonado O, Jury N, Lasagna-Reeves CA. Cisternas P, et al. Among authors: lasagna reeves ca. Brain Commun. 2022 Sep 19;4(5):fcac235. doi: 10.1093/braincomms/fcac235. eCollection 2022. Brain Commun. 2022. PMID: 36196088 Free PMC article.
43 results