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Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression.
Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD. Varela-Eirín M, et al. Among authors: largo r. Cell Death Dis. 2022 Aug 5;13(8):681. doi: 10.1038/s41419-022-05089-w. Cell Death Dis. 2022. PMID: 35931686 Free PMC article.
Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis.
Varela-Eirín M, Varela-Vázquez A, Guitián-Caamaño A, Paíno CL, Mato V, Largo R, Aasen T, Tabernero A, Fonseca E, Kandouz M, Caeiro JR, Blanco A, Mayán MD. Varela-Eirín M, et al. Among authors: largo r. Cell Death Dis. 2018 Dec 5;9(12):1166. doi: 10.1038/s41419-018-1225-2. Cell Death Dis. 2018. PMID: 30518918 Free PMC article.
Chondrocyte enlargement is a marker of osteoarthritis severity.
Gratal P, Mediero A, Sánchez-Pernaute O, Prieto-Potin I, Lamuedra A, Herrero-Beaumont G, Largo R. Gratal P, et al. Among authors: largo r. Osteoarthritis Cartilage. 2019 Aug;27(8):1229-1234. doi: 10.1016/j.joca.2019.04.013. Epub 2019 Apr 30. Osteoarthritis Cartilage. 2019. PMID: 31051241 Free article.
Editorial: Inflammation and Biomarkers in Osteoarthritis.
Mobasheri A, Fonseca JE, Gualillo O, Henrotin Y, Largo R, Herrero-Beaumont G, Rocha FAC. Mobasheri A, et al. Among authors: largo r. Front Med (Lausanne). 2021 Jul 27;8:727700. doi: 10.3389/fmed.2021.727700. eCollection 2021. Front Med (Lausanne). 2021. PMID: 34386512 Free PMC article. No abstract available.
Osteoarthritis associated with estrogen deficiency.
Roman-Blas JA, Castañeda S, Largo R, Herrero-Beaumont G. Roman-Blas JA, et al. Among authors: largo r. Arthritis Res Ther. 2009;11(5):241. doi: 10.1186/ar2791. Epub 2009 Sep 21. Arthritis Res Ther. 2009. PMID: 19804619 Free PMC article. Review.
326 results