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PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.
Keng VW, Rahrmann EP, Watson AL, Tschida BR, Moertel CL, Jessen WJ, Rizvi TA, Collins MH, Ratner N, Largaespada DA. Keng VW, et al. Among authors: largaespada da. Cancer Res. 2012 Jul 1;72(13):3405-13. doi: 10.1158/0008-5472.CAN-11-4092. Epub 2012 Jun 14. Cancer Res. 2012. PMID: 22700876 Free PMC article.
Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.
Watson AL, Rahrmann EP, Moriarity BS, Choi K, Conboy CB, Greeley AD, Halfond AL, Anderson LK, Wahl BR, Keng VW, Rizzardi AE, Forster CL, Collins MH, Sarver AL, Wallace MR, Schmechel SC, Ratner N, Largaespada DA. Watson AL, et al. Among authors: largaespada da. Cancer Discov. 2013 Jun;3(6):674-89. doi: 10.1158/2159-8290.CD-13-0081. Epub 2013 Mar 27. Cancer Discov. 2013. PMID: 23535903 Free PMC article.
Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.
Rahrmann EP, Watson AL, Keng VW, Choi K, Moriarity BS, Beckmann DA, Wolf NK, Sarver A, Collins MH, Moertel CL, Wallace MR, Gel B, Serra E, Ratner N, Largaespada DA. Rahrmann EP, et al. Among authors: largaespada da. Nat Genet. 2013 Jul;45(7):756-66. doi: 10.1038/ng.2641. Epub 2013 May 19. Nat Genet. 2013. PMID: 23685747 Free PMC article.
MMuFLR: missense mutation and frameshift location reporter.
Rathe SK, Johnson JE, Silverstein KA, Erdmann JJ, Watson AL, Popescu FE, Ohlfest JR, Largaespada DA. Rathe SK, et al. Among authors: largaespada da. Bioinformatics. 2013 Sep 15;29(18):2353-4. doi: 10.1093/bioinformatics/btt385. Epub 2013 Jul 3. Bioinformatics. 2013. PMID: 23825368 Free PMC article.
Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity.
Watson AL, Anderson LK, Greeley AD, Keng VW, Rahrmann EP, Halfond AL, Powell NM, Collins MH, Rizvi T, Moertel CL, Ratner N, Largaespada DA. Watson AL, et al. Among authors: largaespada da. Oncotarget. 2014 Mar 30;5(6):1502-14. doi: 10.18632/oncotarget.1609. Oncotarget. 2014. PMID: 24681606 Free PMC article.
Simple and efficient methods for enrichment and isolation of endonuclease modified cells.
Moriarity BS, Rahrmann EP, Beckmann DA, Conboy CB, Watson AL, Carlson DF, Olson ER, Hyland KA, Fahrenkrug SC, McIvor RS, Largaespada DA. Moriarity BS, et al. Among authors: largaespada da. PLoS One. 2014 May 5;9(5):e96114. doi: 10.1371/journal.pone.0096114. eCollection 2014. PLoS One. 2014. PMID: 24798371 Free PMC article.
237 results