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The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes.
Dong S, Hiam-Galvez KJ, Mowery CT, Herold KC, Gitelman SE, Esensten JH, Liu W, Lares AP, Leinbach AS, Lee M, Nguyen V, Tamaki SJ, Tamaki W, Tamaki CM, Mehdizadeh M, Putnam AL, Spitzer MH, Ye CJ, Tang Q, Bluestone JA. Dong S, et al. Among authors: lares ap. JCI Insight. 2021 Sep 22;6(18):e147474. doi: 10.1172/jci.insight.147474. JCI Insight. 2021. PMID: 34324441 Free PMC article. Clinical Trial.
Type 1 diabetes immunotherapy using polyclonal regulatory T cells.
Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q. Bluestone JA, et al. Sci Transl Med. 2015 Nov 25;7(315):315ra189. doi: 10.1126/scitranslmed.aad4134. Sci Transl Med. 2015. PMID: 26606968 Free PMC article. Clinical Trial.
Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy.
Seay HR, Putnam AL, Cserny J, Posgai AL, Rosenau EH, Wingard JR, Girard KF, Kraus M, Lares AP, Brown HL, Brown KS, Balavage KT, Peters LD, Bushdorf AN, Atkinson MA, Bluestone JA, Haller MJ, Brusko TM. Seay HR, et al. Among authors: lares ap. Mol Ther Methods Clin Dev. 2016 Dec 24;4:178-191. doi: 10.1016/j.omtm.2016.12.003. eCollection 2017 Mar 17. Mol Ther Methods Clin Dev. 2016. PMID: 28345003 Free PMC article.
Adoptive Treg Cell Therapy in a Patient With Systemic Lupus Erythematosus.
Dall'Era M, Pauli ML, Remedios K, Taravati K, Sandova PM, Putnam AL, Lares A, Haemel A, Tang Q, Hellerstein M, Fitch M, McNamara J, Welch B, Bluestone JA, Wofsy D, Rosenblum MD; Autoimmunity Centers of Excellence. Dall'Era M, et al. Arthritis Rheumatol. 2019 Mar;71(3):431-440. doi: 10.1002/art.40737. Epub 2019 Jan 24. Arthritis Rheumatol. 2019. PMID: 30277008 Free PMC article.
Polyclonal Regulatory T Cell Manufacturing Under cGMP: A Decade of Experience.
Balcerek J, Shy BR, Putnam AL, Masiello LM, Lares A, Dekovic F, Acevedo L, Lee MR, Nguyen V, Liu W, Paruthiyil S, Xu J, Leinbach AS, Bluestone JA, Tang Q, Esensten JH. Balcerek J, et al. Front Immunol. 2021 Nov 18;12:744763. doi: 10.3389/fimmu.2021.744763. eCollection 2021. Front Immunol. 2021. PMID: 34867967 Free PMC article.
Selective decrease of donor-reactive Tregs after liver transplantation limits Treg therapy for promoting allograft tolerance in humans.
Tang Q, Leung J, Peng Y, Sanchez-Fueyo A, Lozano JJ, Lam A, Lee K, Greenland JR, Hellerstein M, Fitch M, Li KW, Esensten JH, Putnam AL, Lares A, Nguyen V, Liu W, Bridges ND, Odim J, Demetris AJ, Levitsky J, Taner T, Feng S. Tang Q, et al. Sci Transl Med. 2022 Nov 2;14(669):eabo2628. doi: 10.1126/scitranslmed.abo2628. Epub 2022 Nov 2. Sci Transl Med. 2022. PMID: 36322627 Free PMC article. Clinical Trial.