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PanErbB-targeted CAR T-cell immunotherapy of head and neck cancer.
Expert Opin Biol Ther. 2020 Sep;20(9):965-970. doi: 10.1080/14712598.2020.1786531. Epub 2020 Jun 28.
Expert Opin Biol Ther. 2020.
PMID: 32567382
No abstract available.
Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.
Kosti P, Opzoomer JW, Larios-Martinez KI, Henley-Smith R, Scudamore CL, Okesola M, Taher MYM, Davies DM, Muliaditan T, Larcombe-Young D, Woodman N, Gillett CE, Thavaraj S, Maher J, Arnold JN.
Kosti P, et al. Among authors: larcombe young d.
Cell Rep Med. 2021 Apr 9;2(4):100227. doi: 10.1016/j.xcrm.2021.100227. eCollection 2021 Apr 20.
Cell Rep Med. 2021.
PMID: 33948568
Free PMC article.
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Generation of human parallel chimeric antigen receptor (pCAR) T cells to achieve synergistic T cell co-stimulation.
Larcombe-Young D, Whilding L, Davies DM, Draper B, Bechman N, Maher J.
Larcombe-Young D, et al.
STAR Protoc. 2022 May 21;3(2):101414. doi: 10.1016/j.xpro.2022.101414. eCollection 2022 Jun 17.
STAR Protoc. 2022.
PMID: 35620078
Free PMC article.
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Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation.
Halim L, Das KK, Larcombe-Young D, Ajina A, Candelli A, Benjamin R, Dillon R, Davies DM, Maher J.
Halim L, et al. Among authors: larcombe young d.
Front Immunol. 2022 Feb 9;13:836549. doi: 10.3389/fimmu.2022.836549. eCollection 2022.
Front Immunol. 2022.
PMID: 35222427
Free PMC article.
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Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors.
Muliaditan T, Halim L, Whilding LM, Draper B, Achkova DY, Kausar F, Glover M, Bechman N, Arulappu A, Sanchez J, Flaherty KR, Obajdin J, Grigoriadis K, Antoine P, Larcombe-Young D, Hull CM, Buus R, Gordon P, Grigoriadis A, Davies DM, Schurich A, Maher J.
Muliaditan T, et al. Among authors: larcombe young d.
Cell Rep Med. 2021 Dec 21;2(12):100457. doi: 10.1016/j.xcrm.2021.100457. eCollection 2021 Dec 21.
Cell Rep Med. 2021.
PMID: 35028604
Free PMC article.
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Anti-Folate Receptor Alpha-Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer.
Cheung A, Opzoomer J, Ilieva KM, Gazinska P, Hoffmann RM, Mirza H, Marlow R, Francesch-Domenech E, Fittall M, Dominguez Rodriguez D, Clifford A, Badder L, Patel N, Mele S, Pellizzari G, Bax HJ, Crescioli S, Petranyi G, Larcombe-Young D, Josephs DH, Canevari S, Figini M, Pinder S, Nestle FO, Gillett C, Spicer JF, Grigoriadis A, Tutt ANJ, Karagiannis SN.
Cheung A, et al. Among authors: larcombe young d.
Clin Cancer Res. 2018 Oct 15;24(20):5098-5111. doi: 10.1158/1078-0432.CCR-18-0652. Epub 2018 Aug 1.
Clin Cancer Res. 2018.
PMID: 30068707
Free PMC article.
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Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug Conjugates (ADCs).
Hoffmann RM, Mele S, Cheung A, Larcombe-Young D, Bucaite G, Sachouli E, Zlatareva I, Morad HOJ, Marlow R, McDonnell JM, Figini M, Lacy KE, Tutt AJN, Spicer JF, Thurston DE, Karagiannis SN, Crescioli S.
Hoffmann RM, et al. Among authors: larcombe young d.
Sci Rep. 2020 Jun 1;10(1):8869. doi: 10.1038/s41598-020-65860-x.
Sci Rep. 2020.
PMID: 32483228
Free PMC article.
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Engineering a Dual Specificity γδ T-Cell Receptor for Cancer Immunotherapy.
Davies DM, Pugliese G, Parente Pereira AC, Whilding LM, Larcombe-Young D, Maher J.
Davies DM, et al. Among authors: larcombe young d.
Biology (Basel). 2024 Mar 20;13(3):196. doi: 10.3390/biology13030196.
Biology (Basel). 2024.
PMID: 38534465
Free PMC article.
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