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PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation.
Iannotta L, Emanuele M, Favetta G, Tombesi G, Vandewynckel L, Lara Ordóñez AJ, Saliou JM, Drouyer M, Sibran W, Civiero L, Nichols RJ, Athanasopoulos PS, Kortholt A, Chartier-Harlin MC, Greggio E, Taymans JM. Iannotta L, et al. Among authors: lara ordonez aj. Front Mol Neurosci. 2023 Dec 18;16:1269387. doi: 10.3389/fnmol.2023.1269387. eCollection 2023. Front Mol Neurosci. 2023. PMID: 38169846 Free PMC article.
Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement.
Fdez E, Madero-Pérez J, Lara Ordóñez AJ, Naaldijk Y, Fasiczka R, Aiastui A, Ruiz-Martínez J, López de Munain A, Cowley SA, Wade-Martins R, Hilfiker S. Fdez E, et al. Among authors: lara ordonez aj. iScience. 2022 May 30;25(6):104476. doi: 10.1016/j.isci.2022.104476. eCollection 2022 Jun 17. iScience. 2022. PMID: 35721463 Free PMC article.
Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity.
Fernández B, Chittoor-Vinod VG, Kluss JH, Kelly K, Bryant N, Nguyen APT, Bukhari SA, Smith N, Lara Ordóñez AJ, Fdez E, Chartier-Harlin MC, Montine TJ, Wilson MA, Moore DJ, West AB, Cookson MR, Nichols RJ, Hilfiker S. Fernández B, et al. Among authors: lara ordonez aj. J Parkinsons Dis. 2022;12(5):1423-1447. doi: 10.3233/JPD-213128. J Parkinsons Dis. 2022. PMID: 35599495 Free PMC article.
Rab GTPases in Parkinson's disease: a primer.
Lara Ordóñez AJ, Fasiczka R, Naaldijk Y, Hilfiker S. Lara Ordóñez AJ, et al. Essays Biochem. 2021 Dec 22;65(7):961-974. doi: 10.1042/EBC20210016. Essays Biochem. 2021. PMID: 34414419 Free PMC article.
Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients.
Fernández B, Lara Ordóñez AJ, Fdez E, Mutez E, Comptdaer T, Leghay C, Kreisler A, Simonin C, Vandewynckel L, Defebvre L, Destée A, Bleuse S, Taymans JM, Chartier-Harlin MC, Hilfiker S. Fernández B, et al. Among authors: lara ordonez aj. Biochem J. 2019 Oct 15;476(19):2797-2813. doi: 10.1042/BCJ20190315. Biochem J. 2019. PMID: 31527116 Free PMC article.
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, Taymans JM, Chartier-Harlin MC, Beilina A, Gonnelli A, Cookson MR, Greggio E, Hilfiker S. Madero-Pérez J, et al. Among authors: lara ordonez aj. Mol Neurodegener. 2018 Jan 23;13(1):3. doi: 10.1186/s13024-018-0235-y. Mol Neurodegener. 2018. PMID: 29357897 Free PMC article.
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