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Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement.
Fdez E, Madero-Pérez J, Lara Ordóñez AJ, Naaldijk Y, Fasiczka R, Aiastui A, Ruiz-Martínez J, López de Munain A, Cowley SA, Wade-Martins R, Hilfiker S. Fdez E, et al. Among authors: lara ordonez aj. iScience. 2022 May 30;25(6):104476. doi: 10.1016/j.isci.2022.104476. eCollection 2022 Jun 17. iScience. 2022. PMID: 35721463 Free PMC article.
LRRK2 and Parkinson's Disease: From Lack of Structure to Gain of Function.
Blanca Ramírez M, Madero-Perez J, Rivero-Rios P, Martinez-Salvador M, Lara Ordonez AJ, Fernandez B, Fdez E, Hilfiker S. Blanca Ramírez M, et al. Among authors: lara ordonez aj. Curr Protein Pept Sci. 2017;18(7):677-686. doi: 10.2174/1389203717666160311121748. Curr Protein Pept Sci. 2017. PMID: 26965688 Review.
LRRK2: from kinase to GTPase to microtubules and back.
Blanca Ramírez M, Lara Ordóñez AJ, Fdez E, Hilfiker S. Blanca Ramírez M, et al. Among authors: lara ordonez aj. Biochem Soc Trans. 2017 Feb 8;45(1):141-146. doi: 10.1042/BST20160333. Biochem Soc Trans. 2017. PMID: 28202667 Review.
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, Taymans JM, Chartier-Harlin MC, Beilina A, Gonnelli A, Cookson MR, Greggio E, Hilfiker S. Madero-Pérez J, et al. Among authors: lara ordonez aj. Mol Neurodegener. 2018 Jan 23;13(1):3. doi: 10.1186/s13024-018-0235-y. Mol Neurodegener. 2018. PMID: 29357897 Free PMC article.
Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients.
Fernández B, Lara Ordóñez AJ, Fdez E, Mutez E, Comptdaer T, Leghay C, Kreisler A, Simonin C, Vandewynckel L, Defebvre L, Destée A, Bleuse S, Taymans JM, Chartier-Harlin MC, Hilfiker S. Fernández B, et al. Among authors: lara ordonez aj. Biochem J. 2019 Oct 15;476(19):2797-2813. doi: 10.1042/BCJ20190315. Biochem J. 2019. PMID: 31527116 Free PMC article.
14 results