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Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase.
Savardekar H, Allen C, Jeon H, Li J, Quiroga D, Schwarz E, Wu RC, Zelinskas S, Lapurga G, Abreo A, Stiff A, Shaffer J, Blaser BW, Old M, Wesolowski R, Xin G, Kendra KL, Chung D, Carson WE 3rd. Savardekar H, et al. Among authors: lapurga g. Mol Cancer Res. 2024 Mar 1;22(3):308-321. doi: 10.1158/1541-7786.MCR-22-0572. Mol Cancer Res. 2024. PMID: 38015751
BTK inhibition potentiates anti-PD-L1 treatment in murine melanoma: potential role for MDSC modulation in immunotherapy.
Sun SH, Angell CD, Savardekar H, Sundi D, Abood D, Benner B, DiVincenzo MJ, Duggan M, Choueiry F, Mace T, Trikha P, Lapurga G, Johnson C, Carlson EJ, Chung C, Peterson BR, Lianbo Yu, Zhao J, Kendra KL, Carson WE 3rd. Sun SH, et al. Among authors: lapurga g. Cancer Immunol Immunother. 2023 Nov;72(11):3461-3474. doi: 10.1007/s00262-023-03497-1. Epub 2023 Aug 2. Cancer Immunol Immunother. 2023. PMID: 37528320 Free PMC article.
Effect of Immune Checkpoint Blockade on Myeloid-Derived Suppressor Cell Populations in Patients With Melanoma.
Sun SH, Benner B, Savardekar H, Lapurga G, Good L, Abood D, Nagle E, Duggan M, Stiff A, DiVincenzo MJ, Suarez-Kelly LP, Campbell A, Yu L, Wesolowski R, Howard H, Shah H, Kendra K, Carson WE. Sun SH, et al. Among authors: lapurga g. Front Immunol. 2021 Oct 12;12:740890. doi: 10.3389/fimmu.2021.740890. eCollection 2021. Front Immunol. 2021. PMID: 34712230 Free PMC article.
Evidence for interaction of the NLRP3 inflammasome and Bruton's tyrosine kinase in tumor-associated macrophages: implications for myeloid cell production of interleukin-1beta.
Benner B, Scarberry L, Stiff A, Duggan MC, Good L, Lapurga G, Butchar JP, Tridandapani S, Carson WE. Benner B, et al. Among authors: lapurga g. Oncoimmunology. 2019 Sep 5;8(11):1659704. doi: 10.1080/2162402X.2019.1659704. eCollection 2019. Oncoimmunology. 2019. PMID: 31646085 Free PMC article.
Generation of monocyte-derived tumor-associated macrophages using tumor-conditioned media provides a novel method to study tumor-associated macrophages in vitro.
Benner B, Scarberry L, Suarez-Kelly LP, Duggan MC, Campbell AR, Smith E, Lapurga G, Jiang K, Butchar JP, Tridandapani S, Howard JH, Baiocchi RA, Mace TA, Carson WE 3rd. Benner B, et al. Among authors: lapurga g. J Immunother Cancer. 2019 May 28;7(1):140. doi: 10.1186/s40425-019-0622-0. J Immunother Cancer. 2019. PMID: 31138333 Free PMC article.