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Assessing atropisomer axial chirality in drug discovery and development.
Laplante SR, D Fader L, Fandrick KR, Fandrick DR, Hucke O, Kemper R, Miller SP, Edwards PJ. Laplante SR, et al. J Med Chem. 2011 Oct 27;54(20):7005-22. doi: 10.1021/jm200584g. Epub 2011 Sep 15. J Med Chem. 2011. PMID: 21848318 Review. No abstract available.
Peptide-based inhibitors of the hepatitis C virus serine protease.
Llinàs-Brunet M, Bailey M, Fazal G, Goulet S, Halmos T, Laplante S, Maurice R, Poirier M, Poupart MA, Thibeault D, Wernic D, Lamarre D. Llinàs-Brunet M, et al. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1713-8. doi: 10.1016/s0960-894x(98)00299-6. Bioorg Med Chem Lett. 1998. PMID: 9873421
Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds.
Beaulieu PL, Gillard J, Bykowski D, Brochu C, Dansereau N, Duceppe JS, Haché B, Jakalian A, Lagacé L, LaPlante S, McKercher G, Moreau E, Perreault S, Stammers T, Thauvette L, Warrington J, Kukolj G. Beaulieu PL, et al. Bioorg Med Chem Lett. 2006 Oct 1;16(19):4987-93. doi: 10.1016/j.bmcl.2006.07.074. Bioorg Med Chem Lett. 2006. PMID: 16908138
The challenge of atropisomerism in drug discovery.
Clayden J, Moran WJ, Edwards PJ, LaPlante SR. Clayden J, et al. Among authors: laplante sr. Angew Chem Int Ed Engl. 2009;48(35):6398-401. doi: 10.1002/anie.200901719. Angew Chem Int Ed Engl. 2009. PMID: 19637174 Review. No abstract available.
N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.
Beaulieu PL, Jolicoeur E, Gillard J, Brochu C, Coulombe R, Dansereau N, Duan J, Garneau M, Jakalian A, Kühn P, Lagacé L, LaPlante S, McKercher G, Perrault S, Poirier M, Poupart MA, Stammers T, Thauvette L, Thavonekham B, Kukolj G. Beaulieu PL, et al. Bioorg Med Chem Lett. 2010 Feb 1;20(3):857-61. doi: 10.1016/j.bmcl.2009.12.101. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20074949
93 results