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Ca-EDTA restores the activity of ceftazidime-avibactam or aztreonam against carbapenemase-producing Klebsiellapneumoniae infections.
Wannigama DL, Sithu Shein AM, Hurst C, Monk PN, Hongsing P, Phattharapornjaroen P, Fox Ditcham WG, Ounjai P, Saethang T, Chantaravisoot N, Wapeesittipan P, Luk-In S, Sae-Joo S, Nilgate S, Rirerm U, Tanasatitchai C, Kueakulpattana N, Laowansiri M, Liao T, Kupwiwat R, Rojanathanes R, Ngamwongsatit N, Tungsanga S, Leelahavanichkul A, Devanga Ragupathi NK, Badavath VN, Hosseini Rad SMA, Kanjanabuch T, Hirankarn N, Storer RJ, Cui L, Amarasiri M, Ishikawa H, Higgins PG, Stick SM, Kicic A, Chatsuwan T, Abe S. Wannigama DL, et al. Among authors: laowansiri m. iScience. 2023 Jun 28;26(7):107215. doi: 10.1016/j.isci.2023.107215. eCollection 2023 Jul 21. iScience. 2023. PMID: 37496674 Free PMC article.
High prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be overcome by colistin-EDTA combination therapy.
Shein AMS, Wannigama DL, Higgins PG, Hurst C, Abe S, Hongsing P, Chantaravisoot N, Saethang T, Luk-In S, Liao T, Nilgate S, Rirerm U, Kueakulpattana N, Srisakul S, Aryukarn A, Laowansiri M, Hao LY, Yonpiam M, Ragupathi NKD, Techawiwattanaboon T, Ngamwongsatit N, Amarasiri M, Ounjai P, Kupwiwat R, Phattharapornjaroen P, Badavath VN, Leelahavanichkul A, Kicic A, Chatsuwan T. Shein AMS, et al. Among authors: laowansiri m. Sci Rep. 2022 Jul 28;12(1):12939. doi: 10.1038/s41598-022-17083-5. Sci Rep. 2022. PMID: 35902639 Free PMC article.
Novel colistin-EDTA combination for successful eradication of colistin-resistant Klebsiella pneumoniae catheter-related biofilm infections.
Shein AMS, Wannigama DL, Higgins PG, Hurst C, Abe S, Hongsing P, Chantaravisoot N, Saethang T, Luk-In S, Liao T, Nilgate S, Rirerm U, Kueakulpattana N, Laowansiri M, Srisakul S, Muhummudaree N, Techawiwattanaboon T, Gan L, Xu C, Kupwiwat R, Phattharapornjaroen P, Rojanathanes R, Leelahavanichkul A, Chatsuwan T. Shein AMS, et al. Among authors: laowansiri m. Sci Rep. 2021 Nov 4;11(1):21676. doi: 10.1038/s41598-021-01052-5. Sci Rep. 2021. PMID: 34737361 Free PMC article.