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Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it.
Saxon LK, Jackson BF, Sugiyama T, Lanyon LE, Price JS. Saxon LK, et al. Among authors: lanyon le. Bone. 2011 Aug;49(2):184-93. doi: 10.1016/j.bone.2011.03.683. Epub 2011 Mar 16. Bone. 2011. PMID: 21419885 Free PMC article.
Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent.
Zaman G, Sunters A, Galea GL, Javaheri B, Saxon LK, Moustafa A, Armstrong VJ, Price JS, Lanyon LE. Zaman G, et al. Among authors: lanyon le. J Biol Chem. 2012 Feb 3;287(6):3946-62. doi: 10.1074/jbc.M111.252742. Epub 2011 Nov 2. J Biol Chem. 2012. PMID: 22049075 Free PMC article.
161 results