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High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.
Gilani A, Pandey V, Garcia V, Agostinucci K, Singh SP, Schragenheim J, Bellner L, Falck JR, Paudyal MP, Capdevila JH, Abraham NG, Laniado Schwartzman M. Gilani A, et al. Among authors: laniado schwartzman m. Am J Physiol Regul Integr Comp Physiol. 2018 Nov 1;315(5):R934-R944. doi: 10.1152/ajpregu.00125.2018. Epub 2018 Aug 8. Am J Physiol Regul Integr Comp Physiol. 2018. PMID: 30088983 Free PMC article.
Proximal tubular-targeted overexpression of the Cyp4a12-20-HETE synthase promotes salt-sensitive hypertension in male mice.
Gilani A, Agostinucci K, Pascale JV, Hossain S, Kandhi S, Pandey V, Garcia V, Nasjletti A, Laniado Schwartzman M. Gilani A, et al. Among authors: laniado schwartzman m. Am J Physiol Regul Integr Comp Physiol. 2020 Jun 17;319(1):R87-95. doi: 10.1152/ajpregu.00089.2020. Online ahead of print. Am J Physiol Regul Integr Comp Physiol. 2020. PMID: 32633545 Free PMC article.
Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE.
Inoue K, Sodhi K, Puri N, Gotlinger KH, Cao J, Rezzani R, Falck JR, Abraham NG, Laniado-Schwartzman M. Inoue K, et al. Among authors: laniado schwartzman m. Am J Physiol Renal Physiol. 2009 Oct;297(4):F875-84. doi: 10.1152/ajprenal.00364.2009. Epub 2009 Aug 12. Am J Physiol Renal Physiol. 2009. PMID: 19675180 Free PMC article.
We have previously reported that adenoviral-mediated delivery of cytochrome P-450 (CYP) 4A2, which catalyzes the synthesis of 20-hydroxyeicosatetraenoic acid (20-HETE), results in endothelial dysfunction and hypertension in Sprague-Dawley (SD) rats (Wang JS, Singh H, Zhang F, Ish …
We have previously reported that adenoviral-mediated delivery of cytochrome P-450 (CYP) 4A2, which catalyzes the synthesis of 20-hydroxyeico …
19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension.
Dakarapu R, Errabelli R, Manthati VL, Michael Adebesin A, Barma DK, Barma D, Garcia V, Zhang F, Laniado Schwartzman M, Falck JR. Dakarapu R, et al. Among authors: laniado schwartzman m. Bioorg Med Chem Lett. 2019 Oct 1;29(19):126616. doi: 10.1016/j.bmcl.2019.08.020. Epub 2019 Aug 13. Bioorg Med Chem Lett. 2019. PMID: 31439380 Free PMC article.
The CYP/20-HETE/GPR75 axis in hypertension.
Froogh G, Garcia V, Laniado Schwartzman M. Froogh G, et al. Among authors: laniado schwartzman m. Adv Pharmacol. 2022;94:1-25. doi: 10.1016/bs.apha.2022.02.003. Epub 2022 Mar 30. Adv Pharmacol. 2022. PMID: 35659370 Free PMC article. Review.
Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension.
Hashimoto R, Joshi SR, Jiang H, Capdevila JH, McMurtry IF, Laniado Schwartzman M, Gupte SA. Hashimoto R, et al. Among authors: laniado schwartzman m. Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H293-H303. doi: 10.1152/ajpheart.00785.2016. Epub 2017 May 26. Am J Physiol Heart Circ Physiol. 2017. PMID: 28550179 Free PMC article.
The renal cytochrome P-450 arachidonic acid system.
Laniado-Schwartzman M, Abraham NG. Laniado-Schwartzman M, et al. Pediatr Nephrol. 1992 Sep;6(5):490-8. doi: 10.1007/BF00874022. Pediatr Nephrol. 1992. PMID: 1457335 Review.
66 results