Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE.
Inoue K, Sodhi K, Puri N, Gotlinger KH, Cao J, Rezzani R, Falck JR, Abraham NG, Laniado-Schwartzman M.
Inoue K, et al. Among authors: laniado schwartzman m.
Am J Physiol Renal Physiol. 2009 Oct;297(4):F875-84. doi: 10.1152/ajprenal.00364.2009. Epub 2009 Aug 12.
Am J Physiol Renal Physiol. 2009.
PMID: 19675180
Free PMC article.
We have previously reported that adenoviral-mediated delivery of cytochrome P-450 (CYP) 4A2, which catalyzes the synthesis of 20-hydroxyeicosatetraenoic acid (20-HETE), results in endothelial dysfunction and hypertension in Sprague-Dawley (SD) rats (Wang JS, Singh H, Zhang F, Ish …
We have previously reported that adenoviral-mediated delivery of cytochrome P-450 (CYP) 4A2, which catalyzes the synthesis of 20-hydroxyeico …