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Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer.
Lu H, Bowler N, Harshyne LA, Craig Hooper D, Krishn SR, Kurtoglu S, Fedele C, Liu Q, Tang HY, Kossenkov AV, Kelly WK, Wang K, Kean RB, Weinreb PH, Yu L, Dutta A, Fortina P, Ertel A, Stanczak M, Forsberg F, Gabrilovich DI, Speicher DW, Altieri DC, Languino LR. Lu H, et al. Among authors: languino lr. Matrix Biol. 2018 Sep;70:20-35. doi: 10.1016/j.matbio.2018.03.009. Epub 2018 Mar 9. Matrix Biol. 2018. PMID: 29530483 Free PMC article.
Prostate cancer sheds the αvβ3 integrin in vivo through exosomes.
Krishn SR, Singh A, Bowler N, Duffy AN, Friedman A, Fedele C, Kurtoglu S, Tripathi SK, Wang K, Hawkins A, Sayeed A, Goswami CP, Thakur ML, Iozzo RV, Peiper SC, Kelly WK, Languino LR. Krishn SR, et al. Among authors: languino lr. Matrix Biol. 2019 Apr;77:41-57. doi: 10.1016/j.matbio.2018.08.004. Epub 2018 Aug 8. Matrix Biol. 2019. PMID: 30098419 Free PMC article.
Urine Extracellular Vesicle GATA2 mRNA Discriminates Biopsy Result in Men with Suspicion of Prostate Cancer.
Woo J, Santasusagna S, Banks J, Pastor-Lopez S, Yadav K, Carceles-Cordon M, Dominguez-Andres A, Den RB, Languino LR, Pippa R, Lallas CD, Lu-Yao G, Kelly WK, Knudsen KE, Rodriguez-Bravo V, Tewari AK, Prats JM, Leiby BE, Gomella LG, Domingo-Domenech J. Woo J, et al. Among authors: languino lr. J Urol. 2020 Oct;204(4):691-700. doi: 10.1097/JU.0000000000001066. Epub 2020 Apr 6. J Urol. 2020. PMID: 32250729 Free PMC article.
Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019.
Giri VN, Knudsen KE, Kelly WK, Cheng HH, Cooney KA, Cookson MS, Dahut W, Weissman S, Soule HR, Petrylak DP, Dicker AP, AlDubayan SH, Toland AE, Pritchard CC, Pettaway CA, Daly MB, Mohler JL, Parsons JK, Carroll PR, Pilarski R, Blanco A, Woodson A, Rahm A, Taplin ME, Polascik TJ, Helfand BT, Hyatt C, Morgans AK, Feng F, Mullane M, Powers J, Concepcion R, Lin DW, Wender R, Mark JR, Costello A, Burnett AL, Sartor O, Isaacs WB, Xu J, Weitzel J, Andriole GL, Beltran H, Briganti A, Byrne L, Calvaresi A, Chandrasekar T, Chen DYT, Den RB, Dobi A, Crawford ED, Eastham J, Eggener S, Freedman ML, Garnick M, Gomella PT, Handley N, Hurwitz MD, Izes J, Karnes RJ, Lallas C, Languino L, Loeb S, Lopez AM, Loughlin KR, Lu-Yao G, Malkowicz SB, Mann M, Mille P, Miner MM, Morgan T, Moreno J, Mucci L, Myers RE, Nielsen SM, O'Neil B, Pinover W, Pinto P, Poage W, Raj GV, Rebbeck TR, Ryan C, Sandler H, Schiewer M, Scott EMD, Szymaniak B, Tester W, Trabulsi EJ, Vapiwala N, Yu EY, Zeigler-Johnson C, Gomella LG. Giri VN, et al. J Clin Oncol. 2020 Aug 20;38(24):2798-2811. doi: 10.1200/JCO.20.00046. Epub 2020 Jun 9. J Clin Oncol. 2020. PMID: 32516092 Free PMC article.
The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis.
Krishn SR, Salem I, Quaglia F, Naranjo NM, Agarwal E, Liu Q, Sarker S, Kopenhaver J, McCue PA, Weinreb PH, Violette SM, Altieri DC, Languino LR. Krishn SR, et al. Among authors: languino lr. J Extracell Vesicles. 2020 May 20;9(1):1763594. doi: 10.1080/20013078.2020.1763594. eCollection 2020. J Extracell Vesicles. 2020. PMID: 32595914 Free PMC article.
Methods for extracellular vesicle isolation from cancer cells.
Salem I, Naranjo NM, Singh A, DeRita R, Krishn SR, Sirman LS, Quaglia F, Duffy A, Bowler N, Sayeed A, Languino LR. Salem I, et al. Among authors: languino lr. Cancer Drug Resist. 2020;3(3):371-384. doi: 10.20517/cdr.2019.118. Epub 2020 Apr 25. Cancer Drug Resist. 2020. PMID: 33062957 Free PMC article.
Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression.
Quaglia F, Krishn SR, Wang Y, Goodrich DW, McCue P, Kossenkov AV, Mandigo AC, Knudsen KE, Weinreb PH, Corey E, Kelly WK, Languino LR. Quaglia F, et al. Among authors: languino lr. PLoS One. 2021 Jan 22;16(1):e0244985. doi: 10.1371/journal.pone.0244985. eCollection 2021. PLoS One. 2021. PMID: 33481853 Free PMC article.
Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells.
Krishn SR, Garcia V, Naranjo NM, Quaglia F, Shields CD, Harris MA, Kossenkov AV, Liu Q, Corey E, Altieri DC, Languino LR. Krishn SR, et al. Among authors: languino lr. Cancer Biol Ther. 2022 Dec 31;23(1):173-185. doi: 10.1080/15384047.2022.2030622. Cancer Biol Ther. 2022. PMID: 35188070 Free PMC article.
158 results