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CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease.
Djelti F, Braudeau J, Hudry E, Dhenain M, Varin J, Bièche I, Marquer C, Chali F, Ayciriex S, Auzeil N, Alves S, Langui D, Potier MC, Laprevote O, Vidaud M, Duyckaerts C, Miles R, Aubourg P, Cartier N. Djelti F, et al. Among authors: langui d. Brain. 2015 Aug;138(Pt 8):2383-98. doi: 10.1093/brain/awv166. Epub 2015 Jul 2. Brain. 2015. PMID: 26141492
Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis.
Ayciriex S, Djelti F, Alves S, Regazzetti A, Gaudin M, Varin J, Langui D, Bièche I, Hudry E, Dargère D, Aubourg P, Auzeil N, Laprévote O, Cartier N. Ayciriex S, et al. Among authors: langui d. Front Mol Neurosci. 2017 Jul 11;10:211. doi: 10.3389/fnmol.2017.00211. eCollection 2017. Front Mol Neurosci. 2017. PMID: 28744197 Free PMC article.
Alterations of Neuronal Lysosomes in Alzheimer's Disease and in APPxPS1-KI Mice.
Androuin A, Thierry M, Boluda S; Brainbank NeuroCEB Neuropathology Network; Baskaran A, Langui D, Duyckaerts C, Potier MC, El Hachimi KH, Delatour B, Marty S. Androuin A, et al. Among authors: langui d. J Alzheimers Dis. 2022;87(1):273-284. doi: 10.3233/JAD-215692. J Alzheimers Dis. 2022. PMID: 35275545 Free article.
The Amyotrophic Lateral Sclerosis M114T PFN1 Mutation Deregulates Alternative Autophagy Pathways and Mitochondrial Homeostasis.
Teyssou E, Chartier L, Roussel D, Perera ND, Nemazanyy I, Langui D, Albert M, Larmonier T, Saker S, Salachas F, Pradat PF, Meininger V, Ravassard P, Côté F, Lobsiger CS, Boillée S, Turner BJ, Seilhean D, Millecamps S. Teyssou E, et al. Among authors: langui d. Int J Mol Sci. 2022 May 19;23(10):5694. doi: 10.3390/ijms23105694. Int J Mol Sci. 2022. PMID: 35628504 Free PMC article.
Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy.
Fournier M, Vitte J, Garrigue J, Langui D, Dullin JP, Saurini F, Hanoun N, Perez-Diaz F, Cornilleau F, Joubert C, Ardila-Osorio H, Traver S, Duchateau R, Goujet-Zalc C, Paleologou K, Lashuel HA, Haass C, Duyckaerts C, Cohen-Salmon C, Kahle PJ, Hamon M, Brice A, Corti O. Fournier M, et al. Among authors: langui d. PLoS One. 2009 Aug 14;4(8):e6629. doi: 10.1371/journal.pone.0006629. PLoS One. 2009. PMID: 19680561 Free PMC article.
43 results