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Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity.
Güner G, Aßfalg M, Zhao K, Dreyer T, Lahiri S, Lo Y, Slivinschi BI, Imhof A, Jocher G, Strohm L, Behrends C, Langosch D, Bronger H, Nimsky C, Bartsch JW, Riddell SR, Steiner H, Lichtenthaler SF. Güner G, et al. Among authors: langosch d. EMBO Mol Med. 2022 Oct 10;14(10):e16084. doi: 10.15252/emmm.202216084. Epub 2022 Sep 7. EMBO Mol Med. 2022. PMID: 36069059 Free PMC article.
Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.
Götz A, Mylonas N, Högel P, Silber M, Heinel H, Menig S, Vogel A, Feyrer H, Huster D, Luy B, Langosch D, Scharnagl C, Muhle-Goll C, Kamp F, Steiner H. Götz A, et al. Among authors: langosch d. Biophys J. 2019 Jun 4;116(11):2103-2120. doi: 10.1016/j.bpj.2019.04.030. Epub 2019 May 3. Biophys J. 2019. PMID: 31130234 Free PMC article.
Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage.
Papadopoulou AA, Stelzer W, Silber M, Schlosser C, Spitz C, Haug-Kröper M, Straub T, Müller SA, Lichtenthaler SF, Muhle-Goll C, Langosch D, Fluhrer R. Papadopoulou AA, et al. Among authors: langosch d. Sci Rep. 2022 Dec 5;12(1):20987. doi: 10.1038/s41598-022-24772-8. Sci Rep. 2022. PMID: 36470941 Free PMC article.
The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase.
Pester O, Barrett PJ, Hornburg D, Hornburg P, Pröbstle R, Widmaier S, Kutzner C, Dürrbaum M, Kapurniotu A, Sanders CR, Scharnagl C, Langosch D. Pester O, et al. Among authors: langosch d. J Am Chem Soc. 2013 Jan 30;135(4):1317-29. doi: 10.1021/ja3112093. Epub 2013 Jan 16. J Am Chem Soc. 2013. PMID: 23265086 Free PMC article.
112 results