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Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.
Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt Adrian J, Calvopiña K, Turrientes MC, Kavanagh ME, Lubriks D, Hinchliffe P, Langley GW, Aboklaish AF, Eneroth A, Backlund M, Baran AG, Nielsen EI, Speake M, Kuka J, Robinson J, Grinberga S, Robinson L, McDonough MA, Rydzik AM, Leissing TM, Jimenez-Castellanos JC, Avison MB, Da Silva Pinto S, Pannifer AD, Martjuga M, Widlake E, Priede M, Hopkins Navratilova I, Gniadkowski M, Belfrage AK, Brandt P, Yli-Kauhaluoma J, Bacque E, Page MGP, Björkling F, Tyrrell JM, Spencer J, Lang PA, Baranczewski P, Cantón R, McElroy SP, Jones PS, Baquero F, Suna E, Morrison A, Walsh TR, Schofield CJ. Brem J, et al. Among authors: langley gw. Nat Chem. 2022 Jan;14(1):15-24. doi: 10.1038/s41557-021-00831-x. Epub 2021 Dec 13. Nat Chem. 2022. PMID: 34903857
Profiling interactions of vaborbactam with metallo-β-lactamases.
Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J. Langley GW, et al. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1981-1984. doi: 10.1016/j.bmcl.2019.05.031. Epub 2019 May 17. Bioorg Med Chem Lett. 2019. PMID: 31171422 Free PMC article.
Inhibition of a viral prolyl hydroxylase.
Langley GW, Abboud MI, Lohans CT, Schofield CJ. Langley GW, et al. Bioorg Med Chem. 2019 Jun 15;27(12):2405-2412. doi: 10.1016/j.bmc.2019.01.018. Epub 2019 Jan 23. Bioorg Med Chem. 2019. PMID: 30737136
Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors.
Holt-Martyn JP, Chowdhury R, Tumber A, Yeh TL, Abboud MI, Lippl K, Lohans CT, Langley GW, Figg W Jr, McDonough MA, Pugh CW, Ratcliffe PJ, Schofield CJ. Holt-Martyn JP, et al. Among authors: langley gw. ChemMedChem. 2020 Feb 5;15(3):270-273. doi: 10.1002/cmdc.201900557. Epub 2019 Dec 3. ChemMedChem. 2020. PMID: 31751494 Free PMC article.
Human histone demethylase KDM6B can catalyse sequential oxidations.
Hopkinson RJ , Langley GW , Belle R , Walport LJ , Dunne K , Münzel M , Salah E , Kawamura A , Claridge TDW , Schofield CJ . Hopkinson RJ , et al. Among authors: langley gw. Chem Commun (Camb). 2018 Jul 12;54(57):7975-7978. doi: 10.1039/c8cc04057e. Chem Commun (Camb). 2018. PMID: 29961803 Free PMC article.