Langkilde AE - Search Results

1

Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery.

Solbak SMØ, Zang J, Narayanan D, Høj LJ, Bucciarelli S, Softley C, Meier S, Langkilde AE, Gotfredsen CH, Sattler M, Bach A. Solbak SMØ, et al. Among authors: langkilde ae. J Med Chem. 2020 Feb 13;63(3):1156-1177. doi: 10.1021/acs.jmedchem.9b01492. Epub 2020 Jan 23. J Med Chem. 2020. PMID: 31922756

2

Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior.

Cholak E, Bucciarelli S, Bugge K, Johansen NT, Vestergaard B, Arleth L, Kragelund BB, Langkilde AE. Cholak E, et al. Among authors: langkilde ae. Biochemistry. 2019 Dec 17;58(50):5052-5065. doi: 10.1021/acs.biochem.9b00925. Epub 2019 Dec 3. Biochemistry. 2019. PMID: 31747254

3

Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion.

Cholak E, Bugge K, Khondker A, Gauger K, Pedraz-Cuesta E, Pedersen ME, Bucciarelli S, Vestergaard B, Pedersen SF, Rheinstädter MC, Langkilde AE, Kragelund BB. Cholak E, et al. Among authors: langkilde ae. FASEB J. 2020 Jun;34(6):7462-7482. doi: 10.1096/fj.202000107R. Epub 2020 Apr 11. FASEB J. 2020. PMID: 32277854

4

The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin.

Skaanning LK, Santoro A, Skamris T, Martinsen JH, D'Ursi AM, Bucciarelli S, Vestergaard B, Bugge K, Langkilde AE, Kragelund BB. Skaanning LK, et al. Among authors: langkilde ae. Biomolecules. 2020 Aug 16;10(8):1192. doi: 10.3390/biom10081192. Biomolecules. 2020. PMID: 32824376 Free PMC article.

5

Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors.

Zang J, Peters F, Cambet Y, Cifuentes-Pagano E, Hissabu MMS, Dustin CM, Svensson LH, Olesen MM, Poulsen MFL, Jacobsen S, Tuelung PS, Narayanan D, Langkilde AE, Gajhede M, Pagano PJ, Jaquet V, Vilhardt F, Bach A. Zang J, et al. Among authors: langkilde ae. J Med Chem. 2023 Nov 9;66(21):14963-15005. doi: 10.1021/acs.jmedchem.3c01548. Epub 2023 Oct 19. J Med Chem. 2023. PMID: 37857466

6

The structural basis of fungal glucuronoyl esterase activity on natural substrates.

Ernst HA, Mosbech C, Langkilde AE, Westh P, Meyer AS, Agger JW, Larsen S. Ernst HA, et al. Among authors: langkilde ae. Nat Commun. 2020 Feb 24;11(1):1026. doi: 10.1038/s41467-020-14833-9. Nat Commun. 2020. PMID: 32094331 Free PMC article.

7

Protein/lipid coaggregates are formed during α-synuclein-induced disruption of lipid bilayers.

van Maarschalkerweerd A, Vetri V, Langkilde AE, Foderà V, Vestergaard B. van Maarschalkerweerd A, et al. Among authors: langkilde ae. Biomacromolecules. 2014 Oct 13;15(10):3643-54. doi: 10.1021/bm500937p. Epub 2014 Sep 26. Biomacromolecules. 2014. PMID: 25210839

8

Methods for structural characterization of prefibrillar intermediates and amyloid fibrils.

Langkilde AE, Vestergaard B. Langkilde AE, et al. FEBS Lett. 2009 Aug 20;583(16):2600-9. doi: 10.1016/j.febslet.2009.05.040. Epub 2009 May 28. FEBS Lett. 2009. PMID: 19481541 Free article. Review.

9

Structural characterization of prefibrillar intermediates and amyloid fibrils by small-angle X-ray scattering.

Langkilde AE, Vestergaard B. Langkilde AE, et al. Methods Mol Biol. 2012;849:137-55. doi: 10.1007/978-1-61779-551-0_10. Methods Mol Biol. 2012. PMID: 22528088

10

Wildtype and A30P mutant alpha-synuclein form different fibril structures.

Nielsen SB, Macchi F, Raccosta S, Langkilde AE, Giehm L, Kyrsting A, Svane AS, Manno M, Christiansen G, Nielsen NC, Oddershede L, Vestergaard B, Otzen DE. Nielsen SB, et al. Among authors: langkilde ae. PLoS One. 2013 Jul 4;8(7):e67713. doi: 10.1371/journal.pone.0067713. Print 2013. PLoS One. 2013. PMID: 23861789 Free PMC article.

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