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Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity.
Régnier M, Polizzi A, Smati S, Lukowicz C, Fougerat A, Lippi Y, Fouché E, Lasserre F, Naylies C, Bétoulières C, Barquissau V, Mouisel E, Bertrand-Michel J, Batut A, Saati TA, Canlet C, Tremblay-Franco M, Ellero-Simatos S, Langin D, Postic C, Wahli W, Loiseau N, Guillou H, Montagner A. Régnier M, et al. Among authors: langin d. Sci Rep. 2020 Apr 16;10(1):6489. doi: 10.1038/s41598-020-63579-3. Sci Rep. 2020. PMID: 32300166 Free PMC article.
Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass.
Girousse A, Tavernier G, Valle C, Moro C, Mejhert N, Dinel AL, Houssier M, Roussel B, Besse-Patin A, Combes M, Mir L, Monbrun L, Bézaire V, Prunet-Marcassus B, Waget A, Vila I, Caspar-Bauguil S, Louche K, Marques MA, Mairal A, Renoud ML, Galitzky J, Holm C, Mouisel E, Thalamas C, Viguerie N, Sulpice T, Burcelin R, Arner P, Langin D. Girousse A, et al. Among authors: langin d. PLoS Biol. 2013;11(2):e1001485. doi: 10.1371/journal.pbio.1001485. Epub 2013 Feb 19. PLoS Biol. 2013. PMID: 23431266 Free PMC article. Clinical Trial.
Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis.
Vila IK, Badin PM, Marques MA, Monbrun L, Lefort C, Mir L, Louche K, Bourlier V, Roussel B, Gui P, Grober J, Štich V, Rossmeislová L, Zakaroff-Girard A, Bouloumié A, Viguerie N, Moro C, Tavernier G, Langin D. Vila IK, et al. Among authors: langin d. Cell Rep. 2014 May 22;7(4):1116-29. doi: 10.1016/j.celrep.2014.03.062. Epub 2014 May 1. Cell Rep. 2014. PMID: 24794440 Free article.
Fatty acids from fat cell lipolysis do not activate an inflammatory response but are stored as triacylglycerols in adipose tissue macrophages.
Caspar-Bauguil S, Kolditz CI, Lefort C, Vila I, Mouisel E, Beuzelin D, Tavernier G, Marques MA, Zakaroff-Girard A, Pecher C, Houssier M, Mir L, Nicolas S, Moro C, Langin D. Caspar-Bauguil S, et al. Among authors: langin d. Diabetologia. 2015 Nov;58(11):2627-36. doi: 10.1007/s00125-015-3719-0. Epub 2015 Aug 6. Diabetologia. 2015. PMID: 26245186
Adipocyte lipolysis and insulin resistance.
Morigny P, Houssier M, Mouisel E, Langin D. Morigny P, et al. Among authors: langin d. Biochimie. 2016 Jun;125:259-66. doi: 10.1016/j.biochi.2015.10.024. Epub 2015 Nov 2. Biochimie. 2016. PMID: 26542285 Review.
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.
Montagner A, Polizzi A, Fouché E, Ducheix S, Lippi Y, Lasserre F, Barquissau V, Régnier M, Lukowicz C, Benhamed F, Iroz A, Bertrand-Michel J, Al Saati T, Cano P, Mselli-Lakhal L, Mithieux G, Rajas F, Lagarrigue S, Pineau T, Loiseau N, Postic C, Langin D, Wahli W, Guillou H. Montagner A, et al. Among authors: langin d. Gut. 2016 Jul;65(7):1202-14. doi: 10.1136/gutjnl-2015-310798. Epub 2016 Feb 1. Gut. 2016. PMID: 26838599 Free PMC article.
White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways.
Barquissau V, Beuzelin D, Pisani DF, Beranger GE, Mairal A, Montagner A, Roussel B, Tavernier G, Marques MA, Moro C, Guillou H, Amri EZ, Langin D. Barquissau V, et al. Among authors: langin d. Mol Metab. 2016 Mar 18;5(5):352-365. doi: 10.1016/j.molmet.2016.03.002. eCollection 2016 May. Mol Metab. 2016. PMID: 27110487 Free PMC article.
309 results