Langendorf CG - Search Results

1

Langendorf CG, Kemp BE. Langendorf CG, et al. Cell Res. 2015 Jan;25(1):5-6. doi: 10.1038/cr.2014.163. Epub 2014 Dec 5. Cell Res. 2015. PMID: 25475061 Free PMC article.

2

ATP sensitive bi-quinoline activator of the AMP-activated protein kinase.

Scott JW, Oakhill JS, Ling NX, Langendorf CG, Foitzik RC, Kemp BE, Issinger OG. Scott JW, et al. Among authors: langendorf cg. Biochem Biophys Res Commun. 2014 Jan 10;443(2):435-40. doi: 10.1016/j.bbrc.2013.11.130. Epub 2013 Dec 8. Biochem Biophys Res Commun. 2014. PMID: 24332941

3

Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

Scott JW, Ling N, Issa SM, Dite TA, O'Brien MT, Chen ZP, Galic S, Langendorf CG, Steinberg GR, Kemp BE, Oakhill JS. Scott JW, et al. Among authors: langendorf cg. Chem Biol. 2014 May 22;21(5):619-27. doi: 10.1016/j.chembiol.2014.03.006. Epub 2014 Apr 17. Chem Biol. 2014. PMID: 24746562

4

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

Scott JW, Galic S, Graham KL, Foitzik R, Ling NX, Dite TA, Issa SM, Langendorf CG, Weng QP, Thomas HE, Kay TW, Birnberg NC, Steinberg GR, Kemp BE, Oakhill JS. Scott JW, et al. Among authors: langendorf cg. Chem Biol. 2015 Jun 18;22(6):705-11. doi: 10.1016/j.chembiol.2015.05.011. Chem Biol. 2015. PMID: 26091167

5

Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder.

Scott JW, Park E, Rodriguiz RM, Oakhill JS, Issa SM, O'Brien MT, Dite TA, Langendorf CG, Wetsel WC, Means AR, Kemp BE. Scott JW, et al. Among authors: langendorf cg. Sci Rep. 2015 Sep 23;5:14436. doi: 10.1038/srep14436. Sci Rep. 2015. PMID: 26395653 Free PMC article.

6

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.

Langendorf CG, Ngoei KRW, Scott JW, Ling NXY, Issa SMA, Gorman MA, Parker MW, Sakamoto K, Oakhill JS, Kemp BE. Langendorf CG, et al. Nat Commun. 2016 Mar 8;7:10912. doi: 10.1038/ncomms10912. Nat Commun. 2016. PMID: 26952388 Free PMC article.

7

Impact of Genetic Variation on Human CaMKK2 Regulation by Ca²⁺-Calmodulin and Multisite Phosphorylation.

O'Brien MT, Oakhill JS, Ling NX, Langendorf CG, Hoque A, Dite TA, Means AR, Kemp BE, Scott JW. O'Brien MT, et al. Among authors: langendorf cg. Sci Rep. 2017 Feb 23;7:43264. doi: 10.1038/srep43264. Sci Rep. 2017. PMID: 28230171 Free PMC article.

8

Fake Inhibitors: AMPK Activation Trumps Inhibition.

Langendorf CG, Scott JW, Kemp BE. Langendorf CG, et al. Cell Chem Biol. 2017 Jul 20;24(7):775-777. doi: 10.1016/j.chembiol.2017.07.005. Cell Chem Biol. 2017. PMID: 28732195 Free article.

9

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.

Dite TA, Ling NXY, Scott JW, Hoque A, Galic S, Parker BL, Ngoei KRW, Langendorf CG, O'Brien MT, Kundu M, Viollet B, Steinberg GR, Sakamoto K, Kemp BE, Oakhill JS. Dite TA, et al. Among authors: langendorf cg. Nat Commun. 2017 Sep 18;8(1):571. doi: 10.1038/s41467-017-00628-y. Nat Commun. 2017. PMID: 28924239 Free PMC article.

10

Visualizing AMPK Drug Binding Sites Through Crystallization of Full-Length Phosphorylated α2β1γ1 Heterotrimer.

Langendorf CG, Oakhill JS, Kemp BE. Langendorf CG, et al. Methods Mol Biol. 2018;1732:15-27. doi: 10.1007/978-1-4939-7598-3_2. Methods Mol Biol. 2018. PMID: 29480466

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