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The natural compound silvestrol is a potent inhibitor of Ebola virus replication.
Biedenkopf N, Lange-Grünweller K, Schulte FW, Weißer A, Müller C, Becker D, Becker S, Hartmann RK, Grünweller A. Biedenkopf N, et al. Among authors: lange grunweller k. Antiviral Res. 2017 Jan;137:76-81. doi: 10.1016/j.antiviral.2016.11.011. Epub 2016 Nov 15. Antiviral Res. 2017. PMID: 27864075
Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (-) and the eIF4A-inhibitor Silvestrol.
Müller C, Obermann W, Schulte FW, Lange-Grünweller K, Oestereich L, Elgner F, Glitscher M, Hildt E, Singh K, Wendel HG, Hartmann RK, Ziebuhr J, Grünweller A. Müller C, et al. Among authors: lange grunweller k. Antiviral Res. 2020 Mar;175:104706. doi: 10.1016/j.antiviral.2020.104706. Epub 2020 Jan 10. Antiviral Res. 2020. PMID: 31931103 Free PMC article.
PEI-complexed LNA antiseeds as miRNA inhibitors.
Thomas M, Lange-Grünweller K, Dayyoub E, Bakowsky U, Weirauch U, Aigner A, Hartmann RK, Grünweller A. Thomas M, et al. Among authors: lange grunweller k. RNA Biol. 2012 Aug;9(8):1088-98. doi: 10.4161/rna.21165. Epub 2012 Aug 1. RNA Biol. 2012. PMID: 22894918 Free PMC article.
Biarylalkyl Carboxylic Acid Derivatives as Novel Antischistosomal Agents.
Mäder P, Blohm AS, Quack T, Lange-Grünweller K, Grünweller A, Hartmann RK, Grevelding CG, Schlitzer M. Mäder P, et al. Among authors: lange grunweller k. ChemMedChem. 2016 Jul 5;11(13):1459-68. doi: 10.1002/cmdc.201600127. Epub 2016 May 9. ChemMedChem. 2016. PMID: 27159334
The proto-oncogene Pim-1 is a target of miR-33a.
Thomas M, Lange-Grünweller K, Weirauch U, Gutsch D, Aigner A, Grünweller A, Hartmann RK. Thomas M, et al. Among authors: lange grunweller k. Oncogene. 2012 Feb 16;31(7):918-28. doi: 10.1038/onc.2011.278. Epub 2011 Jul 11. Oncogene. 2012. PMID: 21743487