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The multitargeted receptor tyrosine kinase inhibitor linifanib (ABT-869) induces apoptosis through an Akt and glycogen synthase kinase 3β-dependent pathway.
Hernandez-Davies JE, Zape JP, Landaw EM, Tan X, Presnell A, Griffith D, Heinrich MC, Glaser KB, Sakamoto KM. Hernandez-Davies JE, et al. Among authors: landaw em. Mol Cancer Ther. 2011 Jun;10(6):949-59. doi: 10.1158/1535-7163.MCT-10-0904. Epub 2011 Apr 6. Mol Cancer Ther. 2011. PMID: 21471285 Free PMC article.
Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.
Aldana-Masangkay GI, Rodriguez-Gonzalez A, Lin T, Ikeda AK, Hsieh YT, Kim YM, Lomenick B, Okemoto K, Landaw EM, Wang D, Mazitschek R, Bradner JE, Sakamoto KM. Aldana-Masangkay GI, et al. Among authors: landaw em. Leuk Lymphoma. 2011 Aug;52(8):1544-55. doi: 10.3109/10428194.2011.570821. Epub 2011 Jun 23. Leuk Lymphoma. 2011. PMID: 21699378 Free PMC article.
CREB is a critical regulator of normal hematopoiesis and leukemogenesis.
Cheng JC, Kinjo K, Judelson DR, Chang J, Wu WS, Schmid I, Shankar DB, Kasahara N, Stripecke R, Bhatia R, Landaw EM, Sakamoto KM. Cheng JC, et al. Blood. 2008 Feb 1;111(3):1182-92. doi: 10.1182/blood-2007-04-083600. Epub 2007 Nov 1. Blood. 2008. PMID: 17975014 Free PMC article.
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