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ApoE promotes the proteolytic degradation of Abeta.
Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, Tontonoz P, Landreth GE. Jiang Q, et al. Neuron. 2008 Jun 12;58(5):681-93. doi: 10.1016/j.neuron.2008.04.010. Neuron. 2008. PMID: 18549781 Free PMC article.
Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease.
Wilkinson BL, Cramer PE, Varvel NH, Reed-Geaghan E, Jiang Q, Szabo A, Herrup K, Lamb BT, Landreth GE. Wilkinson BL, et al. Among authors: lamb bt. Neurobiol Aging. 2012 Jan;33(1):197.e21-32. doi: 10.1016/j.neurobiolaging.2010.06.014. Epub 2010 Aug 8. Neurobiol Aging. 2012. PMID: 20696495 Free PMC article.
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT. Jay TR, et al. Among authors: lamb bt. J Exp Med. 2015 Mar 9;212(3):287-95. doi: 10.1084/jem.20142322. Epub 2015 Mar 2. J Exp Med. 2015. PMID: 25732305 Free PMC article.
Peripheral macrophages not ADept at amyloid clearance.
Jay T, Lamb B, Landreth G. Jay T, et al. J Exp Med. 2015 Oct 19;212(11):1758. doi: 10.1084/jem.21211insight5. J Exp Med. 2015. PMID: 26482143 Free PMC article. No abstract available.
Targeting innate immunity for neurodegenerative disorders of the central nervous system.
Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, Russek-Blum N, Sandusky LA, Selenica ML, Takata K, Teeling J, Town T, Van Eldik LJ. Andreasson KI, et al. J Neurochem. 2016 Sep;138(5):653-93. doi: 10.1111/jnc.13667. J Neurochem. 2016. PMID: 27248001 Free PMC article. Review.
135 results