Lakshmanan U - Search Results

1

Discovery of a Novel Mycobacterial F-ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines.

Hotra A, Ragunathan P, Ng PS, Seankongsuk P, Harikishore A, Sarathy JP, Saw WG, Lakshmanan U, Sae-Lao P, Kalia NP, Shin J, Kalyanasundaram R, Anbarasu S, Parthasarathy K, Pradeep CN, Makhija H, Dröge P, Poulsen A, Tan JHL, Pethe K, Dick T, Bates RW, Grüber G. Hotra A, et al. Among authors: lakshmanan u. Angew Chem Int Ed Engl. 2020 Aug 3;59(32):13295-13304. doi: 10.1002/anie.202002546. Epub 2020 May 26. Angew Chem Int Ed Engl. 2020. PMID: 32337801

2

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption.

Shetty A, Xu Z, Lakshmanan U, Hill J, Choong ML, Chng SS, Yamada Y, Poulsen A, Dick T, Gengenbacher M. Shetty A, et al. Among authors: lakshmanan u. Front Microbiol. 2018 Dec 4;9:2960. doi: 10.3389/fmicb.2018.02960. eCollection 2018. Front Microbiol. 2018. PMID: 30564212 Free PMC article.

3

Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria.

Moreira W, Ngan GJ, Low JL, Poulsen A, Chia BC, Ang MJ, Yap A, Fulwood J, Lakshmanan U, Lim J, Khoo AY, Flotow H, Hill J, Raju RM, Rubin EJ, Dick T. Moreira W, et al. Among authors: lakshmanan u. mBio. 2015 May 5;6(3):e00253-15. doi: 10.1128/mBio.00253-15. mBio. 2015. PMID: 25944857 Free PMC article.

4

Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques.

Koh-Stenta X, Joy J, Poulsen A, Li R, Tan Y, Shim Y, Min JH, Wu L, Ngo A, Peng J, Seetoh WG, Cao J, Wee JL, Kwek PZ, Hung A, Lakshmanan U, Flotow H, Guccione E, Hill J. Koh-Stenta X, et al. Among authors: lakshmanan u. Biochem J. 2014 Jul 15;461(2):323-34. doi: 10.1042/BJ20140374. Biochem J. 2014. PMID: 24785241

5

Establishment of a novel whole animal HTS technology platform for melioidosis drug discovery.

Lakshmanan U, Yap A, Fulwood J, Yichun L, Hoon SS, Lim J, Ting A, Sem XH, Kreisberg JF, Tan P, Tan G, Flotow H. Lakshmanan U, et al. Comb Chem High Throughput Screen. 2014;17(9):790-803. doi: 10.2174/1386207317666141019195031. Comb Chem High Throughput Screen. 2014. PMID: 25329838

6

AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells.

Urbano A, Lakshmanan U, Choo PH, Kwan JC, Ng PY, Guo K, Dhakshinamoorthy S, Porter A. Urbano A, et al. Among authors: lakshmanan u. EMBO J. 2005 Aug 3;24(15):2815-26. doi: 10.1038/sj.emboj.7600746. Epub 2005 Jul 7. EMBO J. 2005. PMID: 16001080 Free PMC article.

7

Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 ).

Lakshmanan U, Porter AG. Lakshmanan U, et al. J Immunol. 2007 Dec 15;179(12):8480-90. doi: 10.4049/jimmunol.179.12.8480. J Immunol. 2007. PMID: 18056395

8

Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with FOXP3 mutations.

Borna Š, Lee E, Nideffer J, Ramachandran A, Wang B, Baker J, Mavers M, Lakshmanan U, Narula M, Garrett AK, Schulze J, Olek S, Marois L, Gernez Y, Bhatia M, Chong HJ, Walter J, Kitcharoensakkul M, Lang A, Cooper MA, Bertaina A, Roncarolo MG, Meffre E, Bacchetta R. Borna Š, et al. Among authors: lakshmanan u. Sci Transl Med. 2023 Dec 20;15(727):eadg6822. doi: 10.1126/scitranslmed.adg6822. Epub 2023 Dec 20. Sci Transl Med. 2023. PMID: 38117899 Free PMC article.

9

Analyses of thymocyte commitment to regulatory T cell lineage in thymus of healthy subjects and patients with 22q11.2 deletion syndrome.

Borna S, Dejene B, Lakshmanan U, Schulze J, Weinberg K, Bacchetta R. Borna S, et al. Among authors: lakshmanan u. Front Immunol. 2023 Mar 8;14:1088059. doi: 10.3389/fimmu.2023.1088059. eCollection 2023. Front Immunol. 2023. PMID: 37006241 Free PMC article.

10

Epigenetic and immunological indicators of IPEX disease in subjects with FOXP3 gene mutation.

Narula M, Lakshmanan U, Borna S, Schulze JJ, Holmes TH, Harre N, Kirkey M, Ramachandran A, Tagi VM, Barzaghi F, Grunebaum E, Upton JEM, Hong-Diep Kim V, Wysocki C, Dimitriades VR, Weinberg K, Weinacht KG, Gernez Y, Sathi BK, Schelotto M, Johnson M, Olek S, Sachsenmaier C, Roncarolo MG, Bacchetta R. Narula M, et al. Among authors: lakshmanan u. J Allergy Clin Immunol. 2023 Jan;151(1):233-246.e10. doi: 10.1016/j.jaci.2022.09.013. Epub 2022 Sep 21. J Allergy Clin Immunol. 2023. PMID: 36152823 Free article.

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