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A conformational switch controlling the toxicity of the prion protein.
Frontzek K, Bardelli M, Senatore A, Henzi A, Reimann RR, Bedir S, Marino M, Hussain R, Jurt S, Meisl G, Pedotti M, Mazzola F, Siligardi G, Zerbe O, Losa M, Knowles T, Lakkaraju A, Zhu C, Schwarz P, Hornemann S, Holt MG, Simonelli L, Varani L, Aguzzi A. Frontzek K, et al. Among authors: lakkaraju a. Nat Struct Mol Biol. 2022 Aug;29(8):831-840. doi: 10.1038/s41594-022-00814-7. Epub 2022 Aug 10. Nat Struct Mol Biol. 2022. PMID: 35948768 Free PMC article.
An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation.
Avar M, Heinzer D, Thackray AM, Liu Y, Hruska-Plochan M, Sellitto S, Schaper E, Pease DP, Yin JA, Lakkaraju AK, Emmenegger M, Losa M, Chincisan A, Hornemann S, Polymenidou M, Bujdoso R, Aguzzi A. Avar M, et al. Among authors: lakkaraju ak. EMBO J. 2022 Dec 1;41(23):e112338. doi: 10.15252/embj.2022112338. Epub 2022 Oct 18. EMBO J. 2022. PMID: 36254605 Free PMC article.
Hyaline fibromatosis syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors.
Deuquet J, Lausch E, Guex N, Abrami L, Salvi S, Lakkaraju A, Ramirez MC, Martignetti JA, Rokicki D, Bonafe L, Superti-Furga A, van der Goot FG. Deuquet J, et al. Among authors: lakkaraju a. EMBO Mol Med. 2011 Apr;3(4):208-21. doi: 10.1002/emmm.201100124. Epub 2011 Feb 15. EMBO Mol Med. 2011. PMID: 21328543 Free PMC article.
Characterization of APOBEC3G binding to 7SL RNA.
Bach D, Peddi S, Mangeat B, Lakkaraju A, Strub K, Trono D. Bach D, et al. Among authors: lakkaraju a. Retrovirology. 2008 Jul 2;5:54. doi: 10.1186/1742-4690-5-54. Retrovirology. 2008. PMID: 18597676 Free PMC article.
Channel Activities of the Full-Length Prion and Truncated Proteins.
Wu J, Wang X, Lakkaraju A, Sternke-Hoffmann R, Qureshi BM, Aguzzi A, Luo J. Wu J, et al. Among authors: lakkaraju a. ACS Chem Neurosci. 2024 Jan 3;15(1):98-107. doi: 10.1021/acschemneuro.3c00412. Epub 2023 Dec 14. ACS Chem Neurosci. 2024. PMID: 38096481
Calreticulin mutations affect its chaperone function and perturb the glycoproteome.
Schürch PM, Malinovska L, Hleihil M, Losa M, Hofstetter MC, Wildschut MHE, Lysenko V, Lakkaraju AKK, Maat CA, Benke D, Aguzzi A, Wollscheid B, Picotti P, Theocharides APA. Schürch PM, et al. Among authors: lakkaraju akk. Cell Rep. 2022 Nov 22;41(8):111689. doi: 10.1016/j.celrep.2022.111689. Cell Rep. 2022. PMID: 36417879 Free article.
60 results