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Year Number of Results
2013 1
2017 1
2018 3
2019 5
2020 4
2021 5
2022 4
2023 4
2024 5

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28 results

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Page 1
Discovery of harmiprims, harmine-primaquine hybrids, as potent and selective anticancer and antimalarial compounds.
Pavić K, Poje G, Pessanha de Carvalho L, Tandarić T, Marinović M, Fontinha D, Held J, Prudêncio M, Piantanida I, Vianello R, Krošl Knežević I, Perković I, Rajić Z. Pavić K, et al. Among authors: pessanha de carvalho l. Bioorg Med Chem. 2024 Apr 23;105:117734. doi: 10.1016/j.bmc.2024.117734. Online ahead of print. Bioorg Med Chem. 2024. PMID: 38677112
Reverse N-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR).
Abdullaziz MA, Takada S, Illarionov B, Pessanha de Carvalho L, Sakamoto Y, Höfmann S, Knak T, Kiffe-Delf AL, Mazzone F, Pfeffer K, Kalscheuer R, Bacher A, Held J, Fischer M, Tanaka N, Kurz T. Abdullaziz MA, et al. Among authors: pessanha de carvalho l. ACS Infect Dis. 2024 Apr 22. doi: 10.1021/acsinfecdis.4c00100. Online ahead of print. ACS Infect Dis. 2024. PMID: 38647213
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application.
Hofer W, Deschner F, Jézéquel G, Pessanha de Carvalho L, Abdel-Wadood N, Pätzold L, Bernecker S, Morgenstern B, Kany AM, Große M, Stadler M, Bischoff M, Hirsch AKH, Held J, Herrmann J, Müller R. Hofer W, et al. Among authors: pessanha de carvalho l. Angew Chem Int Ed Engl. 2024 May 6;63(19):e202319765. doi: 10.1002/anie.202319765. Epub 2024 Apr 3. Angew Chem Int Ed Engl. 2024. PMID: 38502093
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum.
Johannsen S, Gierse RM, Krüger A, Edwards RL, Nanna V, Fontana A, Zhu D, Masini T, de Carvalho LP, Poizat M, Kieftenbelt B, Hodge DM, Alvarez S, Bunt D, Lacour A, Shams A, Meissner KA, de Souza EE, Dröge M, van Vliet B, den Hartog J, Hutter MC, Held J, Odom John AR, Wrenger C, Hirsch AKH. Johannsen S, et al. Among authors: de carvalho lp. ACS Infect Dis. 2024 Mar 8;10(3):1000-1022. doi: 10.1021/acsinfecdis.3c00670. Epub 2024 Feb 17. ACS Infect Dis. 2024. PMID: 38367280 Free PMC article.
The problem of antimalarial resistance and its implications for drug discovery.
Schäfer TM, Pessanha de Carvalho L, Inoue J, Kreidenweiss A, Held J. Schäfer TM, et al. Among authors: pessanha de carvalho l. Expert Opin Drug Discov. 2024 Feb;19(2):209-224. doi: 10.1080/17460441.2023.2284820. Epub 2024 Feb 1. Expert Opin Drug Discov. 2024. PMID: 38108082 Review.
Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults - a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trial.
Ekoka Mbassi D, Mombo-Ngoma G, Held J, Okwu DG, Ndzebe-Ndoumba W, Kalkman LC, Ekoka Mbassi FA, Pessanha de Carvalho L, Inoue J, Akinosho MA, Dimessa Mbadinga LB, Yovo EK, Mordmüller B, Kremsner PG, Adegnika AA, Ramharter M, Zoleko-Manego R. Ekoka Mbassi D, et al. Among authors: pessanha de carvalho l. EBioMedicine. 2023 Nov;97:104814. doi: 10.1016/j.ebiom.2023.104814. Epub 2023 Oct 13. EBioMedicine. 2023. PMID: 37839134 Free PMC article. Clinical Trial.
28 results