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Discovery of Small Molecules for the Reversal of T Cell Exhaustion.
Marro BS, Zak J, Zavareh RB, Teijaro JR, Lairson LL, Oldstone MBA. Marro BS, et al. Among authors: lairson ll. Cell Rep. 2019 Dec 3;29(10):3293-3302.e3. doi: 10.1016/j.celrep.2019.10.119. Cell Rep. 2019. PMID: 31801090 Free PMC article.
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, Lazear MR, Yin S, Blewett MM, Dix MM, Nguyen N, Shokhirev MN, Chin EN, Lairson LL, Melillo B, Schreiber SL, Forli S, Teijaro JR, Cravatt BF. Vinogradova EV, et al. Among authors: lairson ll. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29. Cell. 2020. PMID: 32730809 Free PMC article.
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.
Chin EN, Yu C, Vartabedian VF, Jia Y, Kumar M, Gamo AM, Vernier W, Ali SH, Kissai M, Lazar DC, Nguyen N, Pereira LE, Benish B, Woods AK, Joseph SB, Chu A, Johnson KA, Sander PN, Martínez-Peña F, Hampton EN, Young TS, Wolan DW, Chatterjee AK, Schultz PG, Petrassi HM, Teijaro JR, Lairson LL. Chin EN, et al. Among authors: lairson ll. Science. 2020 Aug 21;369(6506):993-999. doi: 10.1126/science.abb4255. Science. 2020. PMID: 32820126
Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78.
Ambrose AJ, Sivinski J, Zerio CJ, Zhu X, Godek J, Kumirov VK, Coma Brujas T, Torra Garcia J, Annadurai A, Schmidlin CJ, Werner A, Shi T, Zavareh RB, Lairson L, Zhang DD, Chapman E. Ambrose AJ, et al. J Med Chem. 2023 Jan 12;66(1):677-694. doi: 10.1021/acs.jmedchem.2c01631. Epub 2022 Dec 14. J Med Chem. 2023. PMID: 36516003
Small molecule-based approaches to adult stem cell therapies.
Lairson LL, Lyssiotis CA, Zhu S, Schultz PG. Lairson LL, et al. Annu Rev Pharmacol Toxicol. 2013;53:107-25. doi: 10.1146/annurev-pharmtox-011112-140300. Annu Rev Pharmacol Toxicol. 2013. PMID: 23294307 Review.
64 results