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Acetylation site specificities of lysine deacetylase inhibitors in human cells.
Schölz C, Weinert BT, Wagner SA, Beli P, Miyake Y, Qi J, Jensen LJ, Streicher W, McCarthy AR, Westwood NJ, Lain S, Cox J, Matthias P, Mann M, Bradner JE, Choudhary C. Schölz C, et al. Among authors: lain s. Nat Biotechnol. 2015 Apr;33(4):415-23. doi: 10.1038/nbt.3130. Epub 2015 Mar 9. Nat Biotechnol. 2015. PMID: 25751058
Pilot screening programme for small molecule activators of p53.
Berkson RG, Hollick JJ, Westwood NJ, Woods JA, Lane DP, Lain S. Berkson RG, et al. Among authors: lain s. Int J Cancer. 2005 Jul 10;115(5):701-10. doi: 10.1002/ijc.20968. Int J Cancer. 2005. PMID: 15729694 Free article.
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.
Lain S, Hollick JJ, Campbell J, Staples OD, Higgins M, Aoubala M, McCarthy A, Appleyard V, Murray KE, Baker L, Thompson A, Mathers J, Holland SJ, Stark MJ, Pass G, Woods J, Lane DP, Westwood NJ. Lain S, et al. Cancer Cell. 2008 May;13(5):454-63. doi: 10.1016/j.ccr.2008.03.004. Cancer Cell. 2008. PMID: 18455128 Free PMC article.
Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen.
Staples OD, Hollick JJ, Campbell J, Higgins M, McCarthy AR, Appleyard V, Murray KE, Baker L, Thompson A, Ronseaux S, Slawin AM, Lane DP, Westwood NJ, Lain S. Staples OD, et al. Among authors: lain s. Cell Cycle. 2008 Nov 1;7(21):3417-27. doi: 10.4161/cc.7.21.6982. Epub 2008 Nov 15. Cell Cycle. 2008. PMID: 18971638 Free PMC article.
Mechanism-specific signatures for small-molecule p53 activators.
van Leeuwen IM, Higgins M, Campbell J, Brown CJ, McCarthy AR, Pirrie L, Westwood NJ, Laín S. van Leeuwen IM, et al. Among authors: lain s. Cell Cycle. 2011 May 15;10(10):1590-8. doi: 10.4161/cc.10.10.15519. Epub 2011 May 15. Cell Cycle. 2011. PMID: 21490429
150 results