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Blockade of TGF-β and PD-L1 by bintrafusp alfa promotes survival in preclinical ovarian cancer models by promoting T effector and NK cell responses.
Br J Cancer. 2024 Apr 15. doi: 10.1038/s41416-024-02677-9. Online ahead of print.
Br J Cancer. 2024.
PMID: 38622286
Establishing the role of the FES tyrosine kinase in the pathogenesis, pathophysiology, and severity of sepsis and its outcomes.
Laight BJ, Jawa NA, Tyryshkin K, Maslove DM, Boyd JG, Greer PA.
Laight BJ, et al.
Front Immunol. 2023 Apr 14;14:1145826. doi: 10.3389/fimmu.2023.1145826. eCollection 2023.
Front Immunol. 2023.
PMID: 37122758
Free PMC article.
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Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer.
Shakfa N, Li D, Conseil G, Lightbody ED, Wilson-Sanchez J, Hamade A, Chenard S, Jawa NA, Laight BJ, Afriyie-Asante A, Tyryshkin K, Koebel M, Koti M.
Shakfa N, et al. Among authors: laight bj.
J Immunother Cancer. 2023 Apr;11(4):e006170. doi: 10.1136/jitc-2022-006170.
J Immunother Cancer. 2023.
PMID: 37015760
Free PMC article.
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Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy-induced Metastasis.
Hoskin V, Ghaffari A, Laight BJ, SenGupta S, Madarnas Y, Nicol CJB, Elliott BE, Varma S, Greer PA.
Hoskin V, et al. Among authors: laight bj.
Cancer Res Commun. 2022 Jun 17;2(6):456-470. doi: 10.1158/2767-9764.CRC-21-0117. eCollection 2022 Jun.
Cancer Res Commun. 2022.
PMID: 36923551
Free PMC article.
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Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy.
Wedge ME, Jennings VA, Crupi MJF, Poutou J, Jamieson T, Pelin A, Pugliese G, de Souza CT, Petryk J, Laight BJ, Boileau M, Taha Z, Alluqmani N, McKay HE, Pikor L, Khan ST, Azad T, Rezaei R, Austin B, He X, Mansfield D, Rose E, Brown EEF, Crawford N, Alkayyal A, Surendran A, Singaravelu R, Roy DG, Migneco G, McSweeney B, Cottee ML, Jacobus EJ, Keller BA, Yamaguchi TN, Boutros PC, Geoffrion M, Rayner KJ, Chatterjee A, Auer RC, Diallo JS, Gibbings D, tenOever BR, Melcher A, Bell JC, Ilkow CS.
Wedge ME, et al. Among authors: laight bj.
Nat Commun. 2022 Apr 7;13(1):1898. doi: 10.1038/s41467-022-29526-8.
Nat Commun. 2022.
PMID: 35393414
Free PMC article.
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Personalized oncology and BRAFK601N melanoma: model development, drug discovery, and clinical correlation.
Keller BA, Laight BJ, Varette O, Broom A, Wedge MÈ, McSweeney B, Cemeus C, Petryk J, Lo B, Burns B, Nessim C, Ong M, Chica RA, Atkins HL, Diallo JS, Ilkow CS, Bell JC.
Keller BA, et al. Among authors: laight bj.
J Cancer Res Clin Oncol. 2021 May;147(5):1365-1378. doi: 10.1007/s00432-021-03545-2. Epub 2021 Feb 8.
J Cancer Res Clin Oncol. 2021.
PMID: 33555379
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