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Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy.
Zhang J, Chen J, Richardson JP, Francis-Newton NJ, Lai PF, Jenkins K, Major MR, Key RE, Stewart ME, Firth-Clark S, Lloyd SM, Newton GK, Perrior TR, Garrod DR, Robinson C. Zhang J, et al. Among authors: lai pf. ACS Pharmacol Transl Sci. 2022 Aug 12;5(9):735-751. doi: 10.1021/acsptsci.2c00022. eCollection 2022 Sep 9. ACS Pharmacol Transl Sci. 2022. PMID: 36110379 Free PMC article.
The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.
Newton GK, Perrior TR, Jenkins K, Major MR, Key RE, Stewart MR, Firth-Clark S, Lloyd SM, Zhang J, Francis-Newton NJ, Richardson JP, Chen J, Lai P, Garrod DR, Robinson C. Newton GK, et al. J Med Chem. 2014 Nov 26;57(22):9447-62. doi: 10.1021/jm501102h. Epub 2014 Nov 17. J Med Chem. 2014. PMID: 25365789 Free PMC article.
Acute effects of dantrolene on the mechanical performance of myopathic human hearts.
Chakraborty P, Bokhari MM, Massé S, Azam MA, Lai PFH, Liang T, Si D, Bhaskaran A, Riazi S, Billia F, Nanthakumar K. Chakraborty P, et al. Among authors: lai pfh. Heart Rhythm. 2024 Apr 2:S1547-5271(24)02310-5. doi: 10.1016/j.hrthm.2024.03.1815. Online ahead of print. Heart Rhythm. 2024. PMID: 38574788 No abstract available.
Uncoupling cytosolic calcium from membrane voltage by transient receptor potential melastatin 4 channel (TRPM4) modulation: A novel strategy to treat ventricular arrhythmias.
Chakraborty P, Azam MA, Massé S, Lai PFH, Rose RA, Ibarra Moreno CA, Riazi S, Nanthakumar K. Chakraborty P, et al. Among authors: lai pfh. Heart Rhythm O2. 2023 Oct 13;4(11):725-732. doi: 10.1016/j.hroo.2023.10.001. eCollection 2023 Nov. Heart Rhythm O2. 2023. PMID: 38034891 Free PMC article. Review.
Statins Protect Against Early Stages of Doxorubicin-induced Cardiotoxicity Through the Regulation of Akt Signaling and SERCA2.
Dadson K, Thavendiranathan P, Hauck L, Grothe D, Azam MA, Stanley-Hasnain S, Mahiny-Shahmohammady D, Si D, Bokhari M, Lai PFH, Massé S, Nanthakumar K, Billia F. Dadson K, et al. Among authors: lai pfh. CJC Open. 2022 Aug 13;4(12):1043-1052. doi: 10.1016/j.cjco.2022.08.006. eCollection 2022 Dec. CJC Open. 2022. PMID: 36562012 Free PMC article.
Synchronizing systolic calcium release with azumolene in an experimental model.
Si D, Chakraborty P, Azam MA, Nair MKK, Massé S, Lai PFH, Labos C, Riazi S, Nanthakumar K. Si D, et al. Among authors: lai pfh. Heart Rhythm O2. 2022 Jun 15;3(5):568-576. doi: 10.1016/j.hroo.2022.06.001. eCollection 2022 Oct. Heart Rhythm O2. 2022. PMID: 36340488 Free PMC article.
109 results