Lai L - Search Results

1

Engineered domain-inlaid Nme2Cas9 adenine base editors with increased on-target DNA editing and targeting scope.

Zhao D, Gao X, Zhou J, Li J, Qian Y, Wang D, Niu W, Zhang T, Hu M, Xiong H, Lai L, Li Z. Zhao D, et al. Among authors: lai l. BMC Biol. 2023 Nov 9;21(1):250. doi: 10.1186/s12915-023-01754-4. BMC Biol. 2023. PMID: 37946200 Free PMC article.

2

A new compact adenine base editor generated through deletion of HNH and REC2 domain of SpCas9.

Qian Y, Wang D, Niu W, Zhao D, Li J, Liu Z, Gao X, Han Y, Lai L, Li Z. Qian Y, et al. Among authors: lai l. BMC Biol. 2023 Jul 11;21(1):155. doi: 10.1186/s12915-023-01644-9. BMC Biol. 2023. PMID: 37434184 Free PMC article.

3

Development of a highly efficient prime editor system in mice and rabbits.

Qian Y, Wang D, Niu W, Shi Z, Wu M, Zhao D, Li J, Gao X, Zhang Z, Lai L, Li Z. Qian Y, et al. Among authors: lai l. Cell Mol Life Sci. 2023 Nov 4;80(11):346. doi: 10.1007/s00018-023-05003-3. Cell Mol Life Sci. 2023. PMID: 37924393

4

Targeted mutagenesis in mice via an engineered AsCas12f1 system.

Fan P, Wang H, Zhao F, Zhang T, Li J, Sun X, Yu Y, Xiong H, Lai L, Sui T. Fan P, et al. Among authors: lai l. Cell Mol Life Sci. 2024 Jan 28;81(1):63. doi: 10.1007/s00018-023-05100-3. Cell Mol Life Sci. 2024. PMID: 38280977 Free PMC article.

5

Genome-edited rabbits: Unleashing the potential of a promising experimental animal model across diverse diseases.

Han Y, Zhou J, Zhang R, Liang Y, Lai L, Li Z. Han Y, et al. Among authors: lai l. Zool Res. 2024 Mar 18;45(2):253-262. doi: 10.24272/j.issn.2095-8137.2023.201. Zool Res. 2024. PMID: 38287906 Free PMC article. Review.

6

Unraveling the role of Xist in X chromosome inactivation: insights from rabbit model and deletion analysis of exons and repeat A.

Liang M, Zhang L, Lai L, Li Z. Liang M, et al. Among authors: lai l. Cell Mol Life Sci. 2024 Mar 29;81(1):156. doi: 10.1007/s00018-024-05151-0. Cell Mol Life Sci. 2024. PMID: 38551746 Free PMC article.

7

CRISPR/Cas9 facilitates investigation of neural circuit disease using human iPSCs: mechanism of epilepsy caused by an SCN1A loss-of-function mutation.

Liu J, Gao C, Chen W, Ma W, Li X, Shi Y, Zhang H, Zhang L, Long Y, Xu H, Guo X, Deng S, Yan X, Yu D, Pan G, Chen Y, Lai L, Liao W, Li Z. Liu J, et al. Among authors: lai l. Transl Psychiatry. 2016 Jan 5;6(1):e703. doi: 10.1038/tp.2015.203. Transl Psychiatry. 2016. PMID: 26731440 Free PMC article.

8

Base editors: development and applications in biomedicine.

Liang Y, Chen F, Wang K, Lai L. Liang Y, et al. Among authors: lai l. Front Med. 2023 Jun;17(3):359-387. doi: 10.1007/s11684-023-1013-y. Epub 2023 Jul 12. Front Med. 2023. PMID: 37434066 Review.

9

Mini-PE, a prime editor with compact Cas9 and truncated reverse transcriptase.

Lan T, Chen H, Tang C, Wei Y, Liu Y, Zhou J, Zhuang Z, Zhang Q, Chen M, Zhou X, Chi Y, Wang J, He Y, Lai L, Zou Q. Lan T, et al. Among authors: lai l. Mol Ther Nucleic Acids. 2023 Aug 18;33:890-897. doi: 10.1016/j.omtn.2023.08.018. eCollection 2023 Sep 12. Mol Ther Nucleic Acids. 2023. PMID: 37680986 Free PMC article.

10

Genome editing in large animals: current status and future prospects.

Zhao J, Lai L, Ji W, Zhou Q. Zhao J, et al. Among authors: lai l. Natl Sci Rev. 2019 May;6(3):402-420. doi: 10.1093/nsr/nwz013. Epub 2019 Jan 31. Natl Sci Rev. 2019. PMID: 34691891 Free PMC article.

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