Lai K - Search Results

1

Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors.

Liu L, Tang M, Pragani R, Whitby FG, Zhang YQ, Balakrishnan B, Fang Y, Karavadhi S, Tao D, LeClair CA, Hall MD, Marugan JJ, Boxer M, Shen M, Hill CP, Lai K, Patnaik S. Liu L, et al. Among authors: lai k. J Med Chem. 2021 Sep 23;64(18):13551-13571. doi: 10.1021/acs.jmedchem.1c00945. Epub 2021 Sep 7. J Med Chem. 2021. PMID: 34491744 Free PMC article.

2

Intracellular galactose-1-phosphate accumulation leads to environmental stress response in yeast model.

Slepak T, Tang M, Addo F, Lai K. Slepak T, et al. Among authors: lai k. Mol Genet Metab. 2005 Nov;86(3):360-71. doi: 10.1016/j.ymgme.2005.08.002. Mol Genet Metab. 2005. PMID: 16169270

3

Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model.

Slepak TI, Tang M, Slepak VZ, Lai K. Slepak TI, et al. Among authors: lai k. Mol Genet Metab. 2007 Sep-Oct;92(1-2):78-87. doi: 10.1016/j.ymgme.2007.06.005. Epub 2007 Jul 20. Mol Genet Metab. 2007. PMID: 17643331 Free PMC article.

4

High-throughput screening for human galactokinase inhibitors.

Wierenga KJ, Lai K, Buchwald P, Tang M. Wierenga KJ, et al. Among authors: lai k. J Biomol Screen. 2008 Jun;13(5):415-23. doi: 10.1177/1087057108318331. Epub 2008 May 19. J Biomol Screen. 2008. PMID: 18490662 Free PMC article.

5

Molecular and biochemical characterization of human galactokinase and its small molecule inhibitors.

Tang M, Wierenga K, Elsas LJ, Lai K. Tang M, et al. Among authors: lai k. Chem Biol Interact. 2010 Dec 5;188(3):376-85. doi: 10.1016/j.cbi.2010.07.025. Epub 2010 Aug 7. Chem Biol Interact. 2010. PMID: 20696150 Free PMC article.

6

Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria.

Tang M, Odejinmi SI, Allette YM, Vankayalapati H, Lai K. Tang M, et al. Among authors: lai k. Bioorg Med Chem. 2011 Oct 1;19(19):5886-95. doi: 10.1016/j.bmc.2011.08.012. Epub 2011 Aug 16. Bioorg Med Chem. 2011. PMID: 21903402 Free PMC article.

7

Innovative therapy for Classic Galactosemia - tale of two HTS.

Tang M, Odejinmi SI, Vankayalapati H, Wierenga KJ, Lai K. Tang M, et al. Among authors: lai k. Mol Genet Metab. 2012 Jan;105(1):44-55. doi: 10.1016/j.ymgme.2011.09.028. Epub 2011 Oct 1. Mol Genet Metab. 2012. PMID: 22018723 Free PMC article. Review.

8

Structure-activity analysis and cell-based optimization of human galactokinase inhibitors.

Odejinmi S, Rascon R, Tang M, Vankayalapati H, Lai K. Odejinmi S, et al. Among authors: lai k. ACS Med Chem Lett. 2011 Sep 8;2(9):667-672. doi: 10.1021/ml200131j. ACS Med Chem Lett. 2011. PMID: 22125663 Free PMC article.

9

Correlation assessment among clinical phenotypes, expression analysis and molecular modeling of 14 novel variations in the human galactose-1-phosphate uridylyltransferase gene.

Tang M, Facchiano A, Rachamadugu R, Calderon F, Mao R, Milanesi L, Marabotti A, Lai K. Tang M, et al. Among authors: lai k. Hum Mutat. 2012 Jul;33(7):1107-15. doi: 10.1002/humu.22093. Epub 2012 Apr 30. Hum Mutat. 2012. PMID: 22461411 Free PMC article.

10

Subfertility and growth restriction in a new galactose-1 phosphate uridylyltransferase (GALT) - deficient mouse model.

Tang M, Siddiqi A, Witt B, Yuzyuk T, Johnson B, Fraser N, Chen W, Rascon R, Yin X, Goli H, Bodamer OA, Lai K. Tang M, et al. Among authors: lai k. Eur J Hum Genet. 2014 Oct;22(10):1172-9. doi: 10.1038/ejhg.2014.12. Epub 2014 Feb 19. Eur J Hum Genet. 2014. PMID: 24549051 Free PMC article.

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