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The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer.
Hopkins TG, Mura M, Al-Ashtal HA, Lahr RM, Abd-Latip N, Sweeney K, Lu H, Weir J, El-Bahrawy M, Steel JH, Ghaem-Maghami S, Aboagye EO, Berman AJ, Blagden SP. Hopkins TG, et al. Among authors: lahr rm. Nucleic Acids Res. 2016 Feb 18;44(3):1227-46. doi: 10.1093/nar/gkv1515. Epub 2015 Dec 29. Nucleic Acids Res. 2016. PMID: 26717985 Free PMC article.
Capturing the Mechanism Underlying TOP mRNA Binding to LARP1.
Cassidy KC, Lahr RM, Kaminsky JC, Mack S, Fonseca BD, Das SR, Berman AJ, Durrant JD. Cassidy KC, et al. Among authors: lahr rm. Structure. 2019 Dec 3;27(12):1771-1781.e5. doi: 10.1016/j.str.2019.10.006. Epub 2019 Oct 31. Structure. 2019. PMID: 31676287 Free PMC article.
mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1.
Jia JJ, Lahr RM, Solgaard MT, Moraes BJ, Pointet R, Yang AD, Celucci G, Graber TE, Hoang HD, Niklaus MR, Pena IA, Hollensen AK, Smith EM, Chaker-Margot M, Anton L, Dajadian C, Livingstone M, Hearnden J, Wang XD, Yu Y, Maier T, Damgaard CK, Berman AJ, Alain T, Fonseca BD. Jia JJ, et al. Among authors: lahr rm. Nucleic Acids Res. 2021 Apr 6;49(6):3461-3489. doi: 10.1093/nar/gkaa1239. Nucleic Acids Res. 2021. PMID: 33398329 Free PMC article.
LARP1 on TOP of ribosome production.
Fonseca BD, Lahr RM, Damgaard CK, Alain T, Berman AJ. Fonseca BD, et al. Among authors: lahr rm. Wiley Interdiscip Rev RNA. 2018 Sep;9(5):e1480. doi: 10.1002/wrna.1480. Epub 2018 May 2. Wiley Interdiscip Rev RNA. 2018. PMID: 29722158 Free PMC article. Review.
15 results