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Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleavage.
Vizetto-Duarte C, Custódio L, Gangadhar KN, Lago JH, Dias C, Matos AM, Neng N, Nogueira JM, Barreira L, Albericio F, Rauter AP, Varela J. Vizetto-Duarte C, et al. Among authors: lago jh. Phytomedicine. 2016 May 15;23(5):550-7. doi: 10.1016/j.phymed.2016.02.008. Epub 2016 Feb 26. Phytomedicine. 2016. PMID: 27064014 Free article.
Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira baccata.
Bruno de Sousa C, Gangadhar KN, Morais TR, Conserva GA, Vizetto-Duarte C, Pereira H, Laurenti MD, Campino L, Levy D, Uemi M, Barreira L, Custódio L, Passero LF, Lago JH, Varela J. Bruno de Sousa C, et al. Among authors: lago jh. Exp Parasitol. 2017 Mar;174:1-9. doi: 10.1016/j.exppara.2017.01.002. Epub 2017 Jan 24. Exp Parasitol. 2017. PMID: 28126391 Free article.
Antitrypanosomal activity and evaluation of the mechanism of action of dehydrodieugenol isolated from Nectandra leucantha (Lauraceae) and its methylated derivative against Trypanosoma cruzi.
Grecco SS, Costa-Silva TA, Jerz G, de Sousa FS, Alves Conserva GA, Mesquita JT, Galuppo MK, Tempone AG, Neves BJ, Andrade CH, Cunha RL, Uemi M, Sartorelli P, Lago JH. Grecco SS, et al. Among authors: lago jh. Phytomedicine. 2017 Jan 15;24:62-67. doi: 10.1016/j.phymed.2016.11.015. Epub 2016 Nov 21. Phytomedicine. 2017. PMID: 28160863
Report of in vitro antileishmanial properties of Iberian macroalgae.
Bruno de Sousa C, Lago JHG, Macridachis J, Oliveira M, Brito L, Vizetto-Duarte C, Florindo C, Hendrickx S, Maes L, Morais T, Uemi M, Neto L, Dionísio L, Cortes S, Barreira L, Custódio L, Alberício F, Campino L, Varela J. Bruno de Sousa C, et al. Nat Prod Res. 2019 Jun;33(12):1778-1782. doi: 10.1080/14786419.2018.1434637. Epub 2018 Feb 9. Nat Prod Res. 2019. PMID: 29424240
212 results