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Myocardin-related transcription factor contributes to renal fibrosis through the regulation of extracellular microenvironment surrounding fibroblasts.
Yamamura Y, Sakai N, Iwata Y, Lagares D, Hara A, Kitajima S, Toyama T, Miyagawa T, Ogura H, Sato K, Oshima M, Nakagawa S, Tamai A, Horikoshi K, Matsuno T, Yamamoto N, Hayashi D, Toyota Y, Kaikoi D, Shimizu M, Tager AM, Wada T. Yamamura Y, et al. Among authors: lagares d. FASEB J. 2023 Jul;37(7):e23005. doi: 10.1096/fj.202201870R. FASEB J. 2023. PMID: 37289107
Fibrosis--a lethal component of systemic sclerosis.
Ho YY, Lagares D, Tager AM, Kapoor M. Ho YY, et al. Among authors: lagares d. Nat Rev Rheumatol. 2014 Jul;10(7):390-402. doi: 10.1038/nrrheum.2014.53. Epub 2014 Apr 22. Nat Rev Rheumatol. 2014. PMID: 24752182 Review.
Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis.
Black KE, Berdyshev E, Bain G, Castelino FV, Shea BS, Probst CK, Fontaine BA, Bronova I, Goulet L, Lagares D, Ahluwalia N, Knipe RS, Natarajan V, Tager AM. Black KE, et al. Among authors: lagares d. FASEB J. 2016 Jun;30(6):2435-50. doi: 10.1096/fj.201500197R. Epub 2016 Mar 22. FASEB J. 2016. PMID: 27006447 Free PMC article.
In blood and multiple tumor types, autotaxin produces LPA from lysophosphatidylcholine (LPC) via lysophospholipase D activity, but alternative enzymatic pathways also exist for LPA production. ...S., Probst, C. K., Fontaine, B. A., Bronova, I., Goulet, L., Lagares, …
In blood and multiple tumor types, autotaxin produces LPA from lysophosphatidylcholine (LPC) via lysophospholipase D activity, but al …
Fibrogenic Lung Injury Induces Non-Cell-Autonomous Fibroblast Invasion.
Ahluwalia N, Grasberger PE, Mugo BM, Feghali-Bostwick C, Pardo A, Selman M, Lagares D, Tager AM. Ahluwalia N, et al. Among authors: lagares d. Am J Respir Cell Mol Biol. 2016 Jun;54(6):831-42. doi: 10.1165/rcmb.2015-0040OC. Am J Respir Cell Mol Biol. 2016. PMID: 26600305 Free PMC article.
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.
Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ. Liu F, et al. Among authors: lagares d. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25502501 Free PMC article. Clinical Trial.
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis.
Lagares D, Ghassemi-Kakroodi P, Tremblay C, Santos A, Probst CK, Franklin A, Santos DM, Grasberger P, Ahluwalia N, Montesi SB, Shea BS, Black KE, Knipe R, Blati M, Baron M, Wu B, Fahmi H, Gandhi R, Pardo A, Selman M, Wu J, Pelletier JP, Martel-Pelletier J, Tager AM, Kapoor M. Lagares D, et al. Nat Med. 2017 Dec;23(12):1405-1415. doi: 10.1038/nm.4419. Epub 2017 Oct 23. Nat Med. 2017. PMID: 29058717 Free PMC article.
Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization.
Funke M, Knudsen L, Lagares D, Ebener S, Probst CK, Fontaine BA, Franklin A, Kellner M, Kühnel M, Matthieu S, Grothausmann R, Chun J, Roberts JD Jr, Ochs M, Tager AM. Funke M, et al. Among authors: lagares d. Am J Respir Cell Mol Biol. 2016 Jul;55(1):105-16. doi: 10.1165/rcmb.2015-0152OC. Am J Respir Cell Mol Biol. 2016. PMID: 27082727 Free PMC article.
46 results