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Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties.
Gilson P, Josa-Prado F, Beauvineau C, Naud-Martin D, Vanwonterghem L, Mahuteau-Betzer F, Moreno A, Falson P, Lafanechère L, Frachet V, Coll JL, Fernando Díaz J, Hurbin A, Busser B. Gilson P, et al. Among authors: lafanechere l. Sci Rep. 2017 Aug 31;7(1):10209. doi: 10.1038/s41598-017-09491-9. Sci Rep. 2017. PMID: 28860487 Free PMC article.
LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers.
Prunier C, Josserand V, Vollaire J, Beerling E, Petropoulos C, Destaing O, Montemagno C, Hurbin A, Prudent R, de Koning L, Kapur R, Cohen PA, Albiges-Rizo C, Coll JL, van Rheenen J, Billaud M, Lafanechère L. Prunier C, et al. Among authors: lafanechere l. Cancer Res. 2016 Jun 15;76(12):3541-52. doi: 10.1158/0008-5472.CAN-15-1864. Epub 2016 May 23. Cancer Res. 2016. PMID: 27216191 Free article.
The pyrrolopyrimidine colchicine-binding site agent PP-13 reduces the metastatic dissemination of invasive cancer cells in vitro and in vivo.
Gilson P, Couvet M, Vanwonterghem L, Henry M, Vollaire J, Baulin V, Werner M, Orlowska A, Josserand V, Mahuteau-Betzer F, Lafanechère L, Coll JL, Busser B, Hurbin A. Gilson P, et al. Among authors: lafanechere l. Biochem Pharmacol. 2019 Feb;160:1-13. doi: 10.1016/j.bcp.2018.12.004. Epub 2018 Dec 7. Biochem Pharmacol. 2019. PMID: 30529691
Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells.
Peronne L, Denarier E, Rai A, Prudent R, Vernet A, Suzanne P, Ramirez-Rios S, Michallet S, Guidetti M, Vollaire J, Lucena-Agell D, Ribba AS, Josserand V, Coll JL, Dallemagne P, Díaz JF, Oliva MÁ, Sadoul K, Akhmanova A, Andrieux A, Lafanechère L. Peronne L, et al. Among authors: lafanechere l. Cancers (Basel). 2020 Aug 6;12(8):2196. doi: 10.3390/cancers12082196. Cancers (Basel). 2020. PMID: 32781579 Free PMC article.
Antitumoral activity of allosteric inhibitors of protein kinase CK2.
Moucadel V, Prudent R, Sautel CF, Teillet F, Barette C, Lafanechere L, Receveur-Brechot V, Cochet C. Moucadel V, et al. Among authors: lafanechere l. Oncotarget. 2011 Dec;2(12):997-1010. doi: 10.18632/oncotarget.361. Oncotarget. 2011. PMID: 22184283 Free PMC article.
Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities.
Prudent R, Vassal-Stermann É, Nguyen CH, Mollaret M, Viallet J, Desroches-Castan A, Martinez A, Barette C, Pillet C, Valdameri G, Soleilhac E, Di Pietro A, Feige JJ, Billaud M, Florent JC, Lafanechère L. Prudent R, et al. Among authors: lafanechere l. Br J Pharmacol. 2013 Feb;168(3):673-85. doi: 10.1111/j.1476-5381.2012.02230.x. Br J Pharmacol. 2013. PMID: 23004938 Free PMC article.
Novel synthetic pharmacophores inducing a stabilization of cellular microtubules.
Martinez A, Soleilhac E, Barette C, Prudent R, Gozzi GJ, Vassal-Stermann E, Pillet C, Di Pietro A, Fauvarque MO, Lafanechere L. Martinez A, et al. Among authors: lafanechere l. Curr Cancer Drug Targets. 2015;15(1):2-13. doi: 10.2174/1568009615666141215154149. Curr Cancer Drug Targets. 2015. PMID: 25543663
75 results