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Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.
Hothorn M, Neumann H, Lenherr ED, Wehner M, Rybin V, Hassa PO, Uttenweiler A, Reinhardt M, Schmidt A, Seiler J, Ladurner AG, Herrmann C, Scheffzek K, Mayer A. Hothorn M, et al. Among authors: ladurner ag. Science. 2009 Apr 24;324(5926):513-6. doi: 10.1126/science.1168120. Science. 2009. PMID: 19390046
The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module.
Stuwe T, Hothorn M, Lejeune E, Rybin V, Bortfeld M, Scheffzek K, Ladurner AG. Stuwe T, et al. Among authors: ladurner ag. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8884-9. doi: 10.1073/pnas.0712293105. Epub 2008 Jun 25. Proc Natl Acad Sci U S A. 2008. PMID: 18579787 Free PMC article.
Splicing regulates NAD metabolite binding to histone macroH2A.
Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG. Kustatscher G, et al. Among authors: ladurner ag. Nat Struct Mol Biol. 2005 Jul;12(7):624-5. doi: 10.1038/nsmb956. Epub 2005 Jun 19. Nat Struct Mol Biol. 2005. PMID: 15965484
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.
Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG. Timinszky G, et al. Among authors: ladurner ag. Nat Struct Mol Biol. 2009 Sep;16(9):923-9. doi: 10.1038/nsmb.1664. Epub 2009 Aug 13. Nat Struct Mol Biol. 2009. PMID: 19680243
The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks.
Ali AAE, Timinszky G, Arribas-Bosacoma R, Kozlowski M, Hassa PO, Hassler M, Ladurner AG, Pearl LH, Oliver AW. Ali AAE, et al. Among authors: ladurner ag. Nat Struct Mol Biol. 2012 Jun 10;19(7):685-692. doi: 10.1038/nsmb.2335. Nat Struct Mol Biol. 2012. PMID: 22683995 Free PMC article.
MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms.
Kozlowski M, Corujo D, Hothorn M, Guberovic I, Mandemaker IK, Blessing C, Sporn J, Gutierrez-Triana A, Smith R, Portmann T, Treier M, Scheffzek K, Huet S, Timinszky G, Buschbeck M, Ladurner AG. Kozlowski M, et al. Among authors: ladurner ag. EMBO Rep. 2018 Oct;19(10):e44445. doi: 10.15252/embr.201744445. Epub 2018 Sep 3. EMBO Rep. 2018. PMID: 30177554 Free PMC article.
A family of macrodomain proteins reverses cellular mono-ADP-ribosylation.
Jankevicius G, Hassler M, Golia B, Rybin V, Zacharias M, Timinszky G, Ladurner AG. Jankevicius G, et al. Among authors: ladurner ag. Nat Struct Mol Biol. 2013 Apr;20(4):508-14. doi: 10.1038/nsmb.2523. Epub 2013 Mar 10. Nat Struct Mol Biol. 2013. PMID: 23474712 Free PMC article.
The macro domain is an ADP-ribose binding module.
Karras GI, Kustatscher G, Buhecha HR, Allen MD, Pugieux C, Sait F, Bycroft M, Ladurner AG. Karras GI, et al. Among authors: ladurner ag. EMBO J. 2005 Jun 1;24(11):1911-20. doi: 10.1038/sj.emboj.7600664. Epub 2005 May 19. EMBO J. 2005. PMID: 15902274 Free PMC article.
99 results