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Identification and Characterization of a Novel Indoleamine 2,3-Dioxygenase 1 Protein Degrader for Glioblastoma.
Bollu LR, Bommi PV, Monsen PJ, Zhai L, Lauing KL, Bell A, Kim M, Ladomersky E, Yang X, Platanias LC, Matei DE, Bonini MG, Munshi HG, Hashizume R, Wu JD, Zhang B, James CD, Chen P, Kocherginsky M, Horbinski C, Cameron MD, Grigorescu AA, Yamini B, Lukas RV, Schiltz GE, Wainwright DA. Bollu LR, et al. Among authors: ladomersky e. J Med Chem. 2022 Dec 8;65(23):15642-15662. doi: 10.1021/acs.jmedchem.2c00771. Epub 2022 Nov 21. J Med Chem. 2022. PMID: 36410047 Free PMC article.
Infiltrating T Cells Increase IDO1 Expression in Glioblastoma and Contribute to Decreased Patient Survival.
Zhai L, Ladomersky E, Lauing KL, Wu M, Genet M, Gritsina G, Győrffy B, Brastianos PK, Binder DC, Sosman JA, Giles FJ, James CD, Horbinski C, Stupp R, Wainwright DA. Zhai L, et al. Among authors: ladomersky e. Clin Cancer Res. 2017 Nov 1;23(21):6650-6660. doi: 10.1158/1078-0432.CCR-17-0120. Epub 2017 Jul 27. Clin Cancer Res. 2017. PMID: 28751450 Free PMC article.
IDO1 in cancer: a Gemini of immune checkpoints.
Zhai L, Ladomersky E, Lenzen A, Nguyen B, Patel R, Lauing KL, Wu M, Wainwright DA. Zhai L, et al. Among authors: ladomersky e. Cell Mol Immunol. 2018 May;15(5):447-457. doi: 10.1038/cmi.2017.143. Epub 2018 Jan 29. Cell Mol Immunol. 2018. PMID: 29375124 Free PMC article. Review.
IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma.
Ladomersky E, Zhai L, Lenzen A, Lauing KL, Qian J, Scholtens DM, Gritsina G, Sun X, Liu Y, Yu F, Gong W, Liu Y, Jiang B, Tang T, Patel R, Platanias LC, James CD, Stupp R, Lukas RV, Binder DC, Wainwright DA. Ladomersky E, et al. Clin Cancer Res. 2018 Jun 1;24(11):2559-2573. doi: 10.1158/1078-0432.CCR-17-3573. Epub 2018 Mar 2. Clin Cancer Res. 2018. PMID: 29500275 Free PMC article.
Commentary: preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma by Garg et al. (2017).
Zhai L, Ladomersky E, Lauing KL, Wu M, Scholtens DM, Savoor R, Zhang B, Wu JD, Horbinski C, Lukas RV, Binder DC, Wainwright DA. Zhai L, et al. Among authors: ladomersky e. Oncoimmunology. 2018 Dec 13;8(3):1548242. doi: 10.1080/2162402X.2018.1548242. eCollection 2019. Oncoimmunology. 2018. PMID: 30723577 Free PMC article.
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