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Intracellular pathways of calcitonin gene-related peptide-induced relaxation of human coronary arteries: A key role for Gβγ subunit instead of cAMP.
de Vries T, Labruijere S, Rivera-Mancilla E, Garrelds IM, de Vries R, Schutter D, van den Bogaerdt A, Poyner DR, Ladds G, Danser AHJ, MaassenVanDenBrink A. de Vries T, et al. Among authors: ladds g. Br J Pharmacol. 2024 Apr 7. doi: 10.1111/bph.16372. Online ahead of print. Br J Pharmacol. 2024. PMID: 38583945
GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.
Gandasi NR, Gao R, Kothegala L, Pearce A, Santos C, Acreman S, Basco D, Benrick A, Chibalina MV, Clark A, Guida C, Harris M, Johnson PRV, Knudsen JG, Ma J, Miranda C, Shigeto M, Tarasov AI, Yeung HY, Thorens B, Asterholm IW, Zhang Q, Ramracheya R, Ladds G, Rorsman P. Gandasi NR, et al. Among authors: ladds g. Diabetologia. 2024 Mar;67(3):528-546. doi: 10.1007/s00125-023-06060-w. Epub 2023 Dec 21. Diabetologia. 2024. PMID: 38127123 Free PMC article.
Dual A1/A3 Adenosine Receptor Antagonists: Binding Kinetics and Structure-Activity Relationship Studies Using Mutagenesis and Alchemical Binding Free Energy Calculations.
Stampelou M, Suchankova A, Tzortzini E, Dhingra L, Barkan K, Lougiakis N, Marakos P, Pouli N, Ladds G, Kolocouris A. Stampelou M, et al. Among authors: ladds g. J Med Chem. 2022 Oct 13;65(19):13305-13327. doi: 10.1021/acs.jmedchem.2c01123. Epub 2022 Sep 29. J Med Chem. 2022. PMID: 36173355
Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression.
Wall MJ, Hill E, Huckstepp R, Barkan K, Deganutti G, Leuenberger M, Preti B, Winfield I, Carvalho S, Suchankova A, Wei H, Safitri D, Huang X, Imlach W, La Mache C, Dean E, Hume C, Hayward S, Oliver J, Zhao FY, Spanswick D, Reynolds CA, Lochner M, Ladds G, Frenguelli BG. Wall MJ, et al. Among authors: ladds g. Nat Commun. 2022 Jul 18;13(1):4150. doi: 10.1038/s41467-022-31652-2. Nat Commun. 2022. PMID: 35851064 Free PMC article.
Discovery of a High Affinity Adenosine A1/A3 Receptor Antagonist with a Novel 7-Amino-pyrazolo[3,4-d]pyridazine Scaffold.
Suchankova A, Stampelou M, Koutsouki K, Pousias A, Dhingra L, Barkan K, Pouli N, Marakos P, Tenta R, Kolocouris A, Lougiakis N, Ladds G. Suchankova A, et al. Among authors: ladds g. ACS Med Chem Lett. 2022 May 31;13(6):923-934. doi: 10.1021/acsmedchemlett.2c00052. eCollection 2022 Jun 9. ACS Med Chem Lett. 2022. PMID: 35707146 Free PMC article.
98 results