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Targeting the binding function 3 (BF3) site of the androgen receptor through virtual screening. 2. development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole derivatives.
Munuganti RS, Leblanc E, Axerio-Cilies P, Labriere C, Frewin K, Singh K, Hassona MD, Lack NA, Li H, Ban F, Tomlinson Guns E, Young R, Rennie PS, Cherkasov A. Munuganti RS, et al. Among authors: lack na. J Med Chem. 2013 Feb 14;56(3):1136-48. doi: 10.1021/jm3015712. Epub 2013 Jan 18. J Med Chem. 2013. PMID: 23301637
Characterization of a new class of androgen receptor antagonists with potential therapeutic application in advanced prostate cancer.
Li H, Hassona MD, Lack NA, Axerio-Cilies P, Leblanc E, Tavassoli P, Kanaan N, Frewin K, Singh K, Adomat H, Böhm KJ, Prinz H, Guns ET, Rennie PS, Cherkasov A. Li H, et al. Among authors: lack na. Mol Cancer Ther. 2013 Nov;12(11):2425-35. doi: 10.1158/1535-7163.MCT-13-0267. Epub 2013 Aug 12. Mol Cancer Ther. 2013. PMID: 23939374
Androgen receptor-binding sites are highly mutated in prostate cancer.
Morova T, McNeill DR, Lallous N, Gönen M, Dalal K, Wilson DM 3rd, Gürsoy A, Keskin Ö, Lack NA. Morova T, et al. Among authors: lack na. Nat Commun. 2020 Feb 11;11(1):832. doi: 10.1038/s41467-020-14644-y. Nat Commun. 2020. PMID: 32047165 Free PMC article.
Functional mapping of androgen receptor enhancer activity.
Huang CF, Lingadahalli S, Morova T, Ozturan D, Hu E, Yu IPL, Linder S, Hoogstraat M, Stelloo S, Sar F, van der Poel H, Altintas UB, Saffarzadeh M, Le Bihan S, McConeghy B, Gokbayrak B, Feng FY, Gleave ME, Bergman AM, Collins C, Hach F, Zwart W, Emberly E, Lack NA. Huang CF, et al. Among authors: lack na. Genome Biol. 2021 May 11;22(1):149. doi: 10.1186/s13059-021-02339-6. Genome Biol. 2021. PMID: 33975627 Free PMC article.
Development of an Androgen Receptor Inhibitor Targeting the N-Terminal Domain of Androgen Receptor for Treatment of Castration Resistant Prostate Cancer.
Ban F, Leblanc E, Cavga AD, Huang CF, Flory MR, Zhang F, Chang MEK, Morin H, Lallous N, Singh K, Gleave ME, Mohammed H, Rennie PS, Lack NA, Cherkasov A. Ban F, et al. Among authors: lack na. Cancers (Basel). 2021 Jul 12;13(14):3488. doi: 10.3390/cancers13143488. Cancers (Basel). 2021. PMID: 34298700 Free PMC article.
60 results