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Mechanotransduction in talin through the interaction of the R8 domain with DLC1.
Haining AWM, Rahikainen R, Cortes E, Lachowski D, Rice A, von Essen M, Hytönen VP, Del Río Hernández A. Haining AWM, et al. Among authors: lachowski d. PLoS Biol. 2018 Jul 20;16(7):e2005599. doi: 10.1371/journal.pbio.2005599. eCollection 2018 Jul. PLoS Biol. 2018. PMID: 30028837 Free PMC article.
FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis.
Lachowski D, Cortes E, Robinson B, Rice A, Rombouts K, Del Río Hernández AE. Lachowski D, et al. FASEB J. 2018 Feb;32(2):1099-1107. doi: 10.1096/fj.201700721R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29070586
Here, we show that FAK controls the nuclear translocation and activation of YAP in response to mechanical activation and submit that the YAP-dependent process of durotaxis requires a cell with an asymmetric distribution of active and inactive FAK molecules.-Lachowski, D …
Here, we show that FAK controls the nuclear translocation and activation of YAP in response to mechanical activation and submit that the YAP …
Retinoic Acid Receptor-β Is Downregulated in Hepatocellular Carcinoma and Cirrhosis and Its Expression Inhibits Myosin-Driven Activation and Durotaxis in Hepatic Stellate Cells.
Cortes E, Lachowski D, Rice A, Chronopoulos A, Robinson B, Thorpe S, Lee DA, Possamai LA, Wang H, Pinato DJ, Del Río Hernández AE. Cortes E, et al. Among authors: lachowski d. Hepatology. 2019 Feb;69(2):785-802. doi: 10.1002/hep.30193. Epub 2018 Dec 17. Hepatology. 2019. PMID: 30055117 Free article.
23 results