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Endothelial cells are not productively infected by SARS-CoV-2.
Schimmel L, Chew KY, Stocks CJ, Yordanov TE, Essebier P, Kulasinghe A, Monkman J, Dos Santos Miggiolaro AFR, Cooper C, de Noronha L, Schroder K, Lagendijk AK, Labzin LI, Short KR, Gordon EJ. Schimmel L, et al. Among authors: labzin li. Clin Transl Immunology. 2021 Oct 24;10(10):e1350. doi: 10.1002/cti2.1350. eCollection 2021. Clin Transl Immunology. 2021. PMID: 34721846 Free PMC article.
Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells.
Zhu Y, Chew KY, Wu M, Karawita AC, McCallum G, Steele LE, Yamamoto A, Labzin LI, Yarlagadda T, Khromykh AA, Wang X, Sng JDJ, Stocks CJ, Xia Y, Kollmann TR, Martino D, Joensuu M, Meunier FA, Balistreri G, Bielefeldt-Ohmann H, Bowen AC, Kicic A, Sly PD, Spann KM, Short KR. Zhu Y, et al. Among authors: labzin li. PLoS Biol. 2022 Aug 1;20(8):e3001728. doi: 10.1371/journal.pbio.3001728. eCollection 2022 Aug. PLoS Biol. 2022. PMID: 35913989 Free PMC article.
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release.
Labzin LI, Chew KY, Eschke K, Wang X, Esposito T, Stocks CJ, Rae J, Patrick R, Mostafavi H, Hill B, Yordanov TE, Holley CL, Emming S, Fritzlar S, Mordant FL, Steinfort DP, Subbarao K, Nefzger CM, Lagendijk AK, Gordon EJ, Parton RG, Short KR, Londrigan SL, Schroder K. Labzin LI, et al. Sci Signal. 2023 Apr 25;16(782):eabq1366. doi: 10.1126/scisignal.abq1366. Epub 2023 Apr 25. Sci Signal. 2023. PMID: 37098119
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages.
Schroder K, Irvine KM, Taylor MS, Bokil NJ, Le Cao KA, Masterman KA, Labzin LI, Semple CA, Kapetanovic R, Fairbairn L, Akalin A, Faulkner GJ, Baillie JK, Gongora M, Daub CO, Kawaji H, McLachlan GJ, Goldman N, Grimmond SM, Carninci P, Suzuki H, Hayashizaki Y, Lenhard B, Hume DA, Sweet MJ. Schroder K, et al. Among authors: labzin li. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):E944-53. doi: 10.1073/pnas.1110156109. Epub 2012 Mar 26. Proc Natl Acad Sci U S A. 2012. PMID: 22451944 Free PMC article.
Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages.
Shakespear MR, Hohenhaus DM, Kelly GM, Kamal NA, Gupta P, Labzin LI, Schroder K, Garceau V, Barbero S, Iyer A, Hume DA, Reid RC, Irvine KM, Fairlie DP, Sweet MJ. Shakespear MR, et al. Among authors: labzin li. J Biol Chem. 2013 Aug 30;288(35):25362-25374. doi: 10.1074/jbc.M113.496281. Epub 2013 Jul 12. J Biol Chem. 2013. PMID: 23853092 Free PMC article.
26 results