Laborde E - Search Results

1

Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function.

Laborde E, Macsata RW, Meng F, Peterson BT, Robinson L, Schow SR, Simon RJ, Xu H, Baba K, Inagaki H, Ishiwata Y, Jomori T, Matsumoto Y, Miyachi A, Nakamura T, Okamoto M, Handel TM, Bernard CC. Laborde E, et al. J Med Chem. 2011 Mar 24;54(6):1667-81. doi: 10.1021/jm1012903. Epub 2011 Feb 22. J Med Chem. 2011. PMID: 21341682 Free PMC article.

2

Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.

Hsu N, Cai D, Damodaran K, Gomez RF, Keck JG, Laborde E, Lum RT, Macke TJ, Martin G, Schow SR, Simon RJ, Villar HO, Wick MM, Beroza P. Hsu N, et al. Among authors: laborde e. J Med Chem. 2004 Sep 23;47(20):4875-80. doi: 10.1021/jm049950b. J Med Chem. 2004. PMID: 15369391

3

Traceless, self-cleaving solid- and solution-phase parallel synthesis of 3,4,7-trisubstituted 3,4-dihydroquinoxalin-2-ones.

Laborde E, Peterson BT, Robinson L. Laborde E, et al. J Comb Chem. 2001 Nov-Dec;3(6):572-7. doi: 10.1021/cc010025+. J Comb Chem. 2001. PMID: 11703154

4

Efficient synthesis of trisubstituted pyrazoles and isoxazoles using a traceless "catch and release" solid-phase strategy.

Ma W, Peterson B, Kelson A, Laborde E. Ma W, et al. Among authors: laborde e. J Comb Chem. 2009 Jul-Aug;11(4):697-703. doi: 10.1021/cc900045t. J Comb Chem. 2009. PMID: 19459688

5

A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo.

Manchem VP, Goldfine ID, Kohanski RA, Cristobal CP, Lum RT, Schow SR, Shi S, Spevak WR, Laborde E, Toavs DK, Villar HO, Wick MM, Kozlowski MR. Manchem VP, et al. Among authors: laborde e. Diabetes. 2001 Apr;50(4):824-30. doi: 10.2337/diabetes.50.4.824. Diabetes. 2001. PMID: 11289048

6

Small molecule activators of the insulin receptor: potential new therapeutic agents for the treatment of diabetes mellitus.

Laborde E, Manchem VP. Laborde E, et al. Curr Med Chem. 2002 Dec;9(24):2231-42. doi: 10.2174/0929867023368665. Curr Med Chem. 2002. PMID: 12470244 Review.

7

Antitumor efficacy and molecular mechanism of TLK58747, a novel DNA-alkylating prodrug.

Xu H, Wang Z, Donaldson JC, Yao H, Zhou S, Kelson AB, Ma W, Weber KT, Laborde E, Cheng M, Sambucetti L, Keck JG. Xu H, et al. Among authors: laborde e. Anticancer Res. 2009 Oct;29(10):3845-55. Anticancer Res. 2009. PMID: 19846918 Free article.

8

Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy.

Domagala JM, Hagen SE, Joannides T, Kiely JS, Laborde E, Schroeder MC, Sesnie JA, Shapiro MA, Suto MJ, Vanderroest S. Domagala JM, et al. Among authors: laborde e. J Med Chem. 1993 Apr 2;36(7):871-82. doi: 10.1021/jm00059a012. J Med Chem. 1993. PMID: 8385225

9

Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death.

Laborde E. Laborde E. Cell Death Differ. 2010 Sep;17(9):1373-80. doi: 10.1038/cdd.2010.80. Epub 2010 Jul 2. Cell Death Differ. 2010. PMID: 20596078 Review.

10

Quinolone antibacterials: synthesis and biological activity of carbon isosteres of the 1-piperazinyl and 3-amino-1-pyrrolidinyl side chains.

Laborde E, Kiely JS, Culbertson TP, Lesheski LE. Laborde E, et al. J Med Chem. 1993 Jul 9;36(14):1964-70. doi: 10.1021/jm00066a005. J Med Chem. 1993. PMID: 8393112

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